{"entities":{"Q84129":{"pageid":74514,"ns":120,"title":"Item:Q84129","lastrevid":455241,"modified":"2026-08-15T09:29:33Z","type":"item","id":"Q84129","labels":{"mul":{"language":"mul","value":"ID_1254443511"},"pt-br":{"language":"pt-br","value":"Encefalite l\u00edmbica autoimune"},"en":{"language":"en","value":"Autoimmune limbic encephalitis"}},"descriptions":{"pt-br":{"language":"pt-br","value":"A encefalite l\u00edmbica autoimune \u00e9 uma doen\u00e7a imunomediada do sistema l\u00edmbico ou dos lobos temporais mediais. A base de tal autoimunidade permanece obscura em muitos casos, mas pode ocorrer ap\u00f3s uma variedade de infec\u00e7\u00f5es virais. Ao contr\u00e1rio da encefalite paraneopl\u00e1sica, um tumor n\u00e3o est\u00e1 presente. Normalmente se manifesta com decl\u00ednio cognitivo rapidamente progressivo, frequentemente com convuls\u00f5es associadas, embora o tronco cerebral e os n\u00facleos da base possam ocorrer. Os pacientes tamb\u00e9m podem se queixar de cefaleia, irritabilidade, dist\u00farbios do sono, del\u00edrios, alucina\u00e7\u00f5es, agita\u00e7\u00e3o e psicose. Os sintomas neurol\u00f3gicos podem responder favoravelmente \u00e0 imunoterapia. As investiga\u00e7\u00f5es podem revelar anormalidades do sinal T2 do lobo temporal mesial na resson\u00e2ncia magn\u00e9tica e um l\u00edquido cefalorraquiano inflamat\u00f3rio._x000D_ _x000D_ Os autoanticorpos neurais associados incluem: anticorpos neurais direcionados a ant\u00edgenos da membrana plasm\u00e1tica, eles s\u00e3o efetores de les\u00e3o (por exemplo, anticorpos de canal de pot\u00e1ssio controlado por voltagem - subtipos LGI1 ou CASPR2)."},"en":{"language":"en","value":"Autoimmune limbic encephalitis is an immune mediated disease of the limbic system or medial temporal lobes. The basis of such autoimmunity remains unclear in many cases but may follow a variety of viral infections. Unlike paraneoplastic encephalitis, a tumour is not present. It typically manifests with rapidly progressive cognitive decline often with accompanying seizures although brainstem and basal ganglia involvement may occur. Patients may also complain of headache, irritability, sleep disturbance, delusions, hallucinations, agitation, and psychosis. Neurological symptoms may respond favourably to immunotherapy. Investigations may reveal mesial temporal lobe T2 signal abnormalities on MRI and an inflammatory spinal fluid. Associated neural autoantibodies include: neural antibodies targeting plasma membrane antigens they are effectors of injury (e.g. voltage gated potassium channel antibodies-LGI1 or CASPR2 subtypes)."}},"aliases":{},"claims":{"P68":[{"mainsnak":{"snaktype":"value","property":"P68","hash":"116a493db7b97933c4d61ad2797053077e039567","datavalue":{"value":"https://id.who.int/icd/entity/1254443511","type":"string"},"datatype":"url"},"type":"statement","id":"Q84129$152DC0F7-0C0B-4ADA-95C0-F7691E2E08B7","rank":"normal"}],"P67":[{"mainsnak":{"snaktype":"value","property":"P67","hash":"d33dcd9a13d6a1e676450ae9ae8244363ccefcb0","datavalue":{"value":"CID11:ID_1254443511","type":"string"},"datatype":"string"},"type":"statement","id":"Q84129$61E80D06-B4A4-4134-B55E-0CCE6E4641CB","rank":"normal"}],"P70":[{"mainsnak":{"snaktype":"value","property":"P70","hash":"5844082b58c49318cc646d7312654cf500b88a63","datavalue":{"value":"dki-india-ID_1254443511","type":"string"},"datatype":"string"},"type":"statement","id":"Q84129$0BA42C34-96C8-4331-B137-23A848A5F253","rank":"normal"}],"P86":[{"mainsnak":{"snaktype":"value","property":"P86","hash":"a96031634b9f5dafddaf781bbba3adea6bb64ef4","datavalue":{"value":"Conclu\u00eddo","type":"string"},"datatype":"string"},"type":"statement","id":"Q84129$46AFE49A-2843-495E-B7AB-947D56BCDA43","rank":"normal"}],"P78":[{"mainsnak":{"snaktype":"value","property":"P78","hash":"5f9b5be68b7400da549761cf15abfdbc4d1e075b","datavalue":{"value":"https://pauloleads.com.br/cases-publicos/","type":"string"},"datatype":"url"},"type":"statement","id":"Q84129$62D826F0-1590-4E3B-8493-B510AE185890","rank":"normal"}],"P80":[{"mainsnak":{"snaktype":"value","property":"P80","hash":"92b8222fcbb75718504f915073a3f43bd4003d18","datavalue":{"value":{"time":"+2026-08-13T00:00:00Z","timezone":0,"before":0,"after":0,"precision":11,"calendarmodel":"http://www.wikidata.org/entity/Q1985727"},"type":"time"},"datatype":"time"},"type":"statement","id":"Q84129$43CF7CF8-6035-4582-956B-566E940C68DC","rank":"normal"}]},"sitelinks":{}}}}