{"entities":{"Q84126":{"pageid":74511,"ns":120,"title":"Item:Q84126","lastrevid":455218,"modified":"2026-08-15T09:29:23Z","type":"item","id":"Q84126","labels":{"mul":{"language":"mul","value":"ID_1445382314"},"pt-br":{"language":"pt-br","value":"Encefalopatia autoimune"},"en":{"language":"en","value":"Autoimmune encephalopathy"}},"descriptions":{"pt-br":{"language":"pt-br","value":"A encefalopatia autoimune \u00e9 semelhante \u00e0 encefalite autoimune [ver defini\u00e7\u00e3o de encefalite autoimune], mas reflete um in\u00edcio mais subagudo a insidioso que tende a flutuar e frequentemente imita dem\u00eancias neurodegenerativas (doen\u00e7a de Creutzfeldt-Jakob ou doen\u00e7a de Lewy Body). Uma hist\u00f3ria pessoal ou familiar de autoimunidade \u00e9 freq\u00fcentemente encontrada. As investiga\u00e7\u00f5es geralmente mostram um l\u00edquido cefalorraquiano inflamat\u00f3rio, um eletroencefalograma epileptiforme e anormalidades de resson\u00e2ncia magn\u00e9tica nos lobos temporais mesiais. Podem ser encontrados autoanticorpos neurais (por exemplo, autoanticorpos complexos de canal de pot\u00e1ssio controlados por voltagem) e n\u00e3o \u00f3rg\u00e3o-espec\u00edficos (anticorpos de peroxidase da tireoide [TPO]). A exclus\u00e3o de etiologias alternativas (por exemplo, infec\u00e7\u00f5es) \u00e9 importante. A resposta \u00e0 imunoterapia pode ser usada para confirmar o diagn\u00f3stico._x000D_ _x000D_ Autoanticorpos associados:_x000D_ _x000D_ DPPX (prote\u00edna semelhante a dipeptidil peptidase-6); GABAAR (autoanticorpos de \u00e1cido gama-aminobut\u00edrico tipo A); gAChR (auto-anticorpos ganglionares para receptores de acetilcolina (subunidade alfa-3)); GAD65 (anticorpos descarboxilase-65 do \u00e1cido glut\u00e2mico); VGKC (LGI1, CASPR2) (anticorpos do complexo do canal de pot\u00e1ssio controlado por voltagem)."},"en":{"language":"en","value":"Autoimmune encephalopathy is similar to autoimmune encephalitis [see autoimmune encephalitis definition] but reflects a more subacute to insidious onset which tends to fluctuate and often mimics neurodegenerative dementias (Creutzfeldt-Jakob disease or Lewy Body disease). A personal or family history of autoimmunity is often found. Investigations typically show an inflammatory spinal fluid, an epileptiform electroencephalogram and MRI abnormalities in the mesial temporal lobes. Accompanying neural autoantibodies (e.g. voltage gated potassium channel complex autoantibodies) and non-organ specific (thyroid peroxidase [TPO] antibodies) may be found. Exclusion of alternative etiologies (e.g. infections) is important. Response to immunotherapy may be used to confirm the diagnosis. Associated autoantibodies: DPPX (dipeptidyl-peptidase\u2013like protein-6); GABAAR (Gamma-aminobutyric-acid type-A autoantibodies); gAChR (ganglionic acetylcholine receptor autoantibodies (alpha-3 subunit)); GAD65 (glutamic acid decarboxylase-65 antibodies); VGKC (LGI1, CASPR2) (voltage gated potassium channel complex antibodies )."}},"aliases":{},"claims":{"P68":[{"mainsnak":{"snaktype":"value","property":"P68","hash":"c99c64feaa4519bca12c9157e872835fa0ea324e","datavalue":{"value":"https://id.who.int/icd/entity/1445382314","type":"string"},"datatype":"url"},"type":"statement","id":"Q84126$F492C305-8700-406F-A939-10A6450C5E56","rank":"normal"}],"P67":[{"mainsnak":{"snaktype":"value","property":"P67","hash":"5651bb6490ccb9276776dea0758a7959df164504","datavalue":{"value":"CID11:ID_1445382314","type":"string"},"datatype":"string"},"type":"statement","id":"Q84126$D2883C0E-9F1B-4FF9-9AD1-D71BFE7B6D06","rank":"normal"}],"P70":[{"mainsnak":{"snaktype":"value","property":"P70","hash":"67bb111c874c39fc7edf9fd36f581f4aa8c1fec5","datavalue":{"value":"dki-india-ID_1445382314","type":"string"},"datatype":"string"},"type":"statement","id":"Q84126$9906E554-8336-4E3C-BCAB-2A5165481001","rank":"normal"}],"P86":[{"mainsnak":{"snaktype":"value","property":"P86","hash":"a96031634b9f5dafddaf781bbba3adea6bb64ef4","datavalue":{"value":"Conclu\u00eddo","type":"string"},"datatype":"string"},"type":"statement","id":"Q84126$9B47912E-4A4D-467C-B5A7-B23ED59C309C","rank":"normal"}],"P78":[{"mainsnak":{"snaktype":"value","property":"P78","hash":"5f9b5be68b7400da549761cf15abfdbc4d1e075b","datavalue":{"value":"https://pauloleads.com.br/cases-publicos/","type":"string"},"datatype":"url"},"type":"statement","id":"Q84126$7669914A-2D71-4F9B-9595-CBC1BC7164E6","rank":"normal"}],"P80":[{"mainsnak":{"snaktype":"value","property":"P80","hash":"92b8222fcbb75718504f915073a3f43bd4003d18","datavalue":{"value":{"time":"+2026-08-13T00:00:00Z","timezone":0,"before":0,"after":0,"precision":11,"calendarmodel":"http://www.wikidata.org/entity/Q1985727"},"type":"time"},"datatype":"time"},"type":"statement","id":"Q84126$F09056C5-75BD-46E0-B4A6-71A15EB43AFB","rank":"normal"}]},"sitelinks":{}}}}