{"entities":{"Q84061":{"pageid":74446,"ns":120,"title":"Item:Q84061","lastrevid":454754,"modified":"2026-08-15T09:25:39Z","type":"item","id":"Q84061","labels":{"mul":{"language":"mul","value":"ID_1599858362"},"pt-br":{"language":"pt-br","value":"S\u00edndrome de hiperexcitabilidade paraneopl\u00e1sica com atividade cont\u00ednua da fibra muscular"},"en":{"language":"en","value":"Paraneoplastic hyperexcitability syndrome with continuous muscle fibre activity"}},"descriptions":{"pt-br":{"language":"pt-br","value":"A s\u00edndrome de hiperexcitabilidade autoimune com atividade cont\u00ednua da fibra muscular (CMFA), \u00e9 uma s\u00edndrome neuromuscular rara caracterizada por fraqueza muscular, frequentemente miocimia, CMFA, \u00e0s vezes uma c\u00e3ibra e s\u00edndrome fascicula\u00e7\u00e3o e caracter\u00edsticas auton\u00f4micas. Parestesia e hiperidrose tamb\u00e9m s\u00e3o comuns. Tamb\u00e9m os sintomas do SNC podem estar associados \u00e0 s\u00edndrome de Morvan. Pode aparecer tanto como uma doen\u00e7a autoimune quanto paraneopl\u00e1sica. Existe uma associa\u00e7\u00e3o com o timoma._x000D_ _x000D_ A doen\u00e7a \u00e9 suavizada por anticorpos mediados em particular com anticorpos do canal de pot\u00e1ssio (VGKC) e o CASPR2 e menos subtipo LGII._x000D_ _x000D_ Ele responde \u00e0 terapia sintom\u00e1tica e terapias imunol\u00f3gicas."},"en":{"language":"en","value":"The autoimmune hyperexcitability syndrome with CMFA, is a rare neuromuscular syndrome characterised by muscle weakness, often myokymia, CMFA, at times a cramp and fasciculation syndrome and autonomic features. Paraesthesia and hyperhydrosis are also common. Also CNS symptoms can be associated in Morvan`s syndrome. It can appear both as an autoimmune- and a paraneoplastic disease. An association with thymoma exists. The disease is soften antibody mediated in particular with potassium channel antibodies ( VGKC) and the CASPR2 and less LGII subtype. It responds to symptomatic therapy and immune therapies."}},"aliases":{},"claims":{"P68":[{"mainsnak":{"snaktype":"value","property":"P68","hash":"2c3343635547775ba84d67f75abdbd2daac0241b","datavalue":{"value":"https://id.who.int/icd/entity/1599858362","type":"string"},"datatype":"url"},"type":"statement","id":"Q84061$FD04C2B6-B328-4FC1-9909-19E87C819451","rank":"normal"}],"P67":[{"mainsnak":{"snaktype":"value","property":"P67","hash":"bdbe6b7a1df335f4cbee654c7742b4959cd556ad","datavalue":{"value":"CID11:ID_1599858362","type":"string"},"datatype":"string"},"type":"statement","id":"Q84061$0F4FCD03-6115-44B7-9396-1429CC0DDF8C","rank":"normal"}],"P70":[{"mainsnak":{"snaktype":"value","property":"P70","hash":"f05be93c21d4d126f244d8ccc9f806ffdfec87b9","datavalue":{"value":"dki-india-ID_1599858362","type":"string"},"datatype":"string"},"type":"statement","id":"Q84061$9ADA2946-52BC-43C0-8D44-A37160A26F46","rank":"normal"}],"P86":[{"mainsnak":{"snaktype":"value","property":"P86","hash":"a96031634b9f5dafddaf781bbba3adea6bb64ef4","datavalue":{"value":"Conclu\u00eddo","type":"string"},"datatype":"string"},"type":"statement","id":"Q84061$9813324F-C8F4-4F92-B451-40D4E66A8EBA","rank":"normal"}],"P78":[{"mainsnak":{"snaktype":"value","property":"P78","hash":"5f9b5be68b7400da549761cf15abfdbc4d1e075b","datavalue":{"value":"https://pauloleads.com.br/cases-publicos/","type":"string"},"datatype":"url"},"type":"statement","id":"Q84061$E1F56E61-4B75-4C01-BA77-90909BA53B2C","rank":"normal"}],"P80":[{"mainsnak":{"snaktype":"value","property":"P80","hash":"92b8222fcbb75718504f915073a3f43bd4003d18","datavalue":{"value":{"time":"+2026-08-13T00:00:00Z","timezone":0,"before":0,"after":0,"precision":11,"calendarmodel":"http://www.wikidata.org/entity/Q1985727"},"type":"time"},"datatype":"time"},"type":"statement","id":"Q84061$60D85F53-A0BA-465F-AAC8-5272E232503F","rank":"normal"}]},"sitelinks":{}}}}