{"entities":{"Q84060":{"pageid":74445,"ns":120,"title":"Item:Q84060","lastrevid":454746,"modified":"2026-08-15T09:25:35Z","type":"item","id":"Q84060","labels":{"mul":{"language":"mul","value":"ID_1155795500"},"pt-br":{"language":"pt-br","value":"S\u00edndrome de hiperexcitabilidade autoimune com atividade cont\u00ednua das fibras musculares ou s\u00edndrome de Morvan"},"en":{"language":"en","value":"Autoimmune hyperexcitability syndrome with continuous muscle fibre activity or Morvan syndrome"}},"descriptions":{"pt-br":{"language":"pt-br","value":"A s\u00edndrome de hiperexcitabilidade autoimune com atividade cont\u00ednua das fibras musculares (CMFA), \u00e9 uma s\u00edndrome neuromuscular rara caracterizada por fraqueza muscular, frequentemente mioquimia, CMFA, \u00e0s vezes uma c\u00e3ibra e s\u00edndrome de fascicula\u00e7\u00e3o e caracter\u00edsticas auton\u00f4micas. Parestesia e hiperidrose tamb\u00e9m s\u00e3o comuns. Tamb\u00e9m os sintomas do SNC podem estar associados \u00e0 s\u00edndrome de Morvan. Pode aparecer tanto como uma doen\u00e7a autoimune quanto paraneopl\u00e1sica. Existe uma associa\u00e7\u00e3o com o timoma._x000D_ A doen\u00e7a \u00e9 frequentemente mediada por anticorpos, em particular com anticorpos do canal de pot\u00e1ssio (VGKC) e anti-CASPR2._x000D_ Ele responde \u00e0 terapia sintom\u00e1tica e terapias imunol\u00f3gicas."},"en":{"language":"en","value":"The autoimmune hyperexcitability syndrome with continuous muscle fibre activity (CMFA), is a rare neuromuscular syndrome characterised by muscle weakness, often myokymia, CMFA, at times a cramp and fasciculation syndrome and autonomic features. Paraesthesia and hyperhydrosis are also common. Also CNS symptoms can be associated in Morvan`s syndrome. It can appear both as an autoimmune- and a paraneoplastic disease. An association with thymoma exists. The disease is often antibody mediated in particular with potassium channel antibodies (VGKC) and anti-CASPR2.  It responds to symptomatic therapy and immune therapies."}},"aliases":{},"claims":{"P68":[{"mainsnak":{"snaktype":"value","property":"P68","hash":"948c4e7df66c467503be07b554bf306dde0ac095","datavalue":{"value":"https://id.who.int/icd/entity/1155795500","type":"string"},"datatype":"url"},"type":"statement","id":"Q84060$89E879A3-EB1B-4CCE-8682-7811E374E3B5","rank":"normal"}],"P67":[{"mainsnak":{"snaktype":"value","property":"P67","hash":"ea70a5bc09884dc950e704ddf69ff2f1bd4229ab","datavalue":{"value":"CID11:ID_1155795500","type":"string"},"datatype":"string"},"type":"statement","id":"Q84060$699E0BEB-17B0-4569-8E2F-B9B43368B84A","rank":"normal"}],"P70":[{"mainsnak":{"snaktype":"value","property":"P70","hash":"f20610cbbe02ca4e6641ef02e494c0799dff3df6","datavalue":{"value":"dki-india-ID_1155795500","type":"string"},"datatype":"string"},"type":"statement","id":"Q84060$8DD3D5B2-FC76-4C0C-A72D-A59BE7299F5D","rank":"normal"}],"P86":[{"mainsnak":{"snaktype":"value","property":"P86","hash":"a96031634b9f5dafddaf781bbba3adea6bb64ef4","datavalue":{"value":"Conclu\u00eddo","type":"string"},"datatype":"string"},"type":"statement","id":"Q84060$FBC8664F-BF58-4CD7-BBDD-4775EAB0482C","rank":"normal"}],"P78":[{"mainsnak":{"snaktype":"value","property":"P78","hash":"5f9b5be68b7400da549761cf15abfdbc4d1e075b","datavalue":{"value":"https://pauloleads.com.br/cases-publicos/","type":"string"},"datatype":"url"},"type":"statement","id":"Q84060$72EE04BD-6AEA-4B4F-B7BC-ECBB8F01BFC6","rank":"normal"}],"P80":[{"mainsnak":{"snaktype":"value","property":"P80","hash":"92b8222fcbb75718504f915073a3f43bd4003d18","datavalue":{"value":{"time":"+2026-08-13T00:00:00Z","timezone":0,"before":0,"after":0,"precision":11,"calendarmodel":"http://www.wikidata.org/entity/Q1985727"},"type":"time"},"datatype":"time"},"type":"statement","id":"Q84060$DDA0A144-D70A-45D6-82DB-E86AB3FB66EE","rank":"normal"}]},"sitelinks":{}}}}