{"entities":{"Q55050":{"pageid":45423,"ns":120,"title":"Item:Q55050","lastrevid":246700,"modified":"2026-08-14T02:41:12Z","type":"item","id":"Q55050","labels":{"mul":{"language":"mul","value":"ID_461002025"},"pt-br":{"language":"pt-br","value":"Xantomatose plana difusa"},"en":{"language":"en","value":"Diffuse plane xanthomatosis"}},"descriptions":{"pt-br":{"language":"pt-br","value":"Doen\u00e7a normolipid\u00eamica rara na qual m\u00faltiplas m\u00e1culas e placas xantomatosas planas se desenvolvem na pele em associa\u00e7\u00e3o com uma paraproteinemia monoclonal. A doen\u00e7a geralmente ocorre em adultos, mas casos raros em crian\u00e7as foram relatados. Os xantomas tipicamente envolvem p\u00e1lpebras, pesco\u00e7o, tronco superior, n\u00e1degas e flexuras. Os lip\u00eddios s\u00e9ricos geralmente s\u00e3o normais. Quase todos os pacientes t\u00eam uma paraprote\u00edna monoclonal circulante que em cerca de metade dos casos est\u00e1 associada a um transtorno mieloproliferativo, especialmente mieloma m\u00faltiplo, leucemia granuloc\u00edtica ou linfoc\u00edtica. Os xantomas surgem como resultado da deposi\u00e7\u00e3o perivascular de complexos lipoprote\u00edna-imunoglobulina."},"en":{"language":"en","value":"This is a rare normolipidaemic disease in which multiple flat xanthomatous macules and plaques develop in the skin in association with a monoclonal paraproteinaemia. The disease generally occurs in adults but rare cases in children have been reported. The xanthomata typically involve the eyelids, neck, upper trunk, buttocks and flexures. Serum lipids are usually normal. Nearly all patients have a circulating monoclonal paraprotein which in about half the cases is associated with a myeloproliferative disorder, especially multiple myeloma, granulocytic or lymphocytic leukaemia. The xanthomata arise as a result of perivascular deposition of lipoprotein\u2013immunoglobulin complexes."}},"aliases":{},"claims":{"P68":[{"mainsnak":{"snaktype":"value","property":"P68","hash":"7c8929c97da0955e03a5c3b7d77f1527ee15b6f8","datavalue":{"value":"https://id.who.int/icd/entity/461002025","type":"string"},"datatype":"url"},"type":"statement","id":"Q55050$5BBAEE82-7C13-4478-B74C-7C83677C0C73","rank":"normal"}],"P67":[{"mainsnak":{"snaktype":"value","property":"P67","hash":"a44ae9ce33cb98124d01e6e1ef57d4146bfc2dd9","datavalue":{"value":"CID11:ID_461002025","type":"string"},"datatype":"string"},"type":"statement","id":"Q55050$5FAB28AB-0CF1-44ED-9180-1FF034EBD756","rank":"normal"}],"P70":[{"mainsnak":{"snaktype":"value","property":"P70","hash":"13851f89377b70d0db1a8c61b46c98a58c3923ff","datavalue":{"value":"dki-india-ID_461002025","type":"string"},"datatype":"string"},"type":"statement","id":"Q55050$D37ECFC4-57B8-4419-B04F-66000D1CB335","rank":"normal"}],"P86":[{"mainsnak":{"snaktype":"value","property":"P86","hash":"a96031634b9f5dafddaf781bbba3adea6bb64ef4","datavalue":{"value":"Conclu\u00eddo","type":"string"},"datatype":"string"},"type":"statement","id":"Q55050$F3DBFD64-605A-4629-9327-C262434EB232","rank":"normal"}],"P78":[{"mainsnak":{"snaktype":"value","property":"P78","hash":"5f9b5be68b7400da549761cf15abfdbc4d1e075b","datavalue":{"value":"https://pauloleads.com.br/cases-publicos/","type":"string"},"datatype":"url"},"type":"statement","id":"Q55050$A6EC31D8-811B-4CA2-A82A-F4CCD77EC0E8","rank":"normal"}],"P80":[{"mainsnak":{"snaktype":"value","property":"P80","hash":"92b8222fcbb75718504f915073a3f43bd4003d18","datavalue":{"value":{"time":"+2026-08-13T00:00:00Z","timezone":0,"before":0,"after":0,"precision":11,"calendarmodel":"http://www.wikidata.org/entity/Q1985727"},"type":"time"},"datatype":"time"},"type":"statement","id":"Q55050$A88C1F38-3382-4735-BDE7-6E5C6E3C81D7","rank":"normal"}]},"sitelinks":{}}}}