{"entities":{"Q46018":{"pageid":36389,"ns":120,"title":"Item:Q46018","lastrevid":177322,"modified":"2026-08-13T14:19:45Z","type":"item","id":"Q46018","labels":{"mul":{"language":"mul","value":"LD20.1"},"pt-br":{"language":"pt-br","value":"S\u00edndromes com lissencefalia como uma caracter\u00edstica importante"},"en":{"language":"en","value":"Syndromes with lissencephaly as a major feature"}},"descriptions":{"pt-br":{"language":"pt-br","value":"O termo lissencefalia abrange um grupo de malforma\u00e7\u00f5es raras que compartilham a caracter\u00edstica comum de anomalias no aparecimento de circunvolu\u00e7\u00f5es cerebrais (caracterizadas por simplifica\u00e7\u00e3o ou aus\u00eancia de dobramento) associadas \u00e0 organiza\u00e7\u00e3o anormal das camadas corticais como resultado de defeitos de migra\u00e7\u00e3o neuronal durante a embriog\u00eanese. Crian\u00e7as com lissencefalia apresentam problemas de alimenta\u00e7\u00e3o e degluti\u00e7\u00e3o, anomalias do t\u00f4nus muscular (hipotonia precoce e subsequentemente hipertonia de membros), convuls\u00f5es (especialmente espasmos infantis) e retardo psicomotor grave. Dois grandes grupos podem ser distinguidos: lissencefalia cl\u00e1ssica (e suas variantes) e lissencefalia em pedra de cal\u00e7ada."},"en":{"language":"en","value":"The term lissencephaly covers a group of rare malformations sharing the common feature of anomalies in the appearance of brain convolutions (characterised by simplification or absence of folding) associated with abnormal organisation of the cortical layers as a result of neuronal migration defects during embryogenesis. Children with lissencephaly have feeding and swallowing problems, muscle tone anomalies (early hypotonia and subsequently limb hypertonia), seizures (in particular, infantile spasms) and severe psychomotor retardation. Two large groups can be distinguished: classical lissencephaly (and its variants) and cobblestone lissencephaly."}},"aliases":{},"claims":{"P68":[{"mainsnak":{"snaktype":"value","property":"P68","hash":"fe9fef9e8cca2c36bf73f9425591014af911a335","datavalue":{"value":"https://id.who.int/icd/entity/805385297","type":"string"},"datatype":"url"},"type":"statement","id":"Q46018$3006C2FE-E392-4B08-B6BA-3598FCD6F94B","rank":"normal"}],"P67":[{"mainsnak":{"snaktype":"value","property":"P67","hash":"02d63ec58332c354f5d9ee94626d37fecfd78175","datavalue":{"value":"CID11:LD20.1","type":"string"},"datatype":"string"},"type":"statement","id":"Q46018$2C5739B1-4F5B-43BE-B9F5-582FD76CA6F3","rank":"normal"}],"P70":[{"mainsnak":{"snaktype":"value","property":"P70","hash":"3f2b2a106bb05e9a04ff0220ea94be08d8df576d","datavalue":{"value":"dki-india-LD20.1","type":"string"},"datatype":"string"},"type":"statement","id":"Q46018$751329F4-8E78-40C1-9BE0-14ABA056D993","rank":"normal"}],"P86":[{"mainsnak":{"snaktype":"value","property":"P86","hash":"a96031634b9f5dafddaf781bbba3adea6bb64ef4","datavalue":{"value":"Conclu\u00eddo","type":"string"},"datatype":"string"},"type":"statement","id":"Q46018$379F04E3-E974-43EC-BCB2-815EE302953D","rank":"normal"}],"P78":[{"mainsnak":{"snaktype":"value","property":"P78","hash":"5f9b5be68b7400da549761cf15abfdbc4d1e075b","datavalue":{"value":"https://pauloleads.com.br/cases-publicos/","type":"string"},"datatype":"url"},"type":"statement","id":"Q46018$B11386BC-6DEE-4306-A9DF-849A862181AD","rank":"normal"}],"P80":[{"mainsnak":{"snaktype":"value","property":"P80","hash":"92b8222fcbb75718504f915073a3f43bd4003d18","datavalue":{"value":{"time":"+2026-08-13T00:00:00Z","timezone":0,"before":0,"after":0,"precision":11,"calendarmodel":"http://www.wikidata.org/entity/Q1985727"},"type":"time"},"datatype":"time"},"type":"statement","id":"Q46018$56FBAD11-C589-411E-AB9D-6B01CC6E8E89","rank":"normal"}],"P89":[{"mainsnak":{"snaktype":"value","property":"P89","hash":"ed2b7863b40be9a7488c7541de25898ec365c304","datavalue":{"value":{"entity-type":"item","numeric-id":21776,"id":"Q21776"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q46018$DF8FE9F1-0B04-4EAA-90B4-BD7E61A31DAF","rank":"normal"}]},"sitelinks":{}}}}