{"entities":{"Q43584":{"pageid":33952,"ns":120,"title":"Item:Q43584","lastrevid":156108,"modified":"2026-08-13T10:39:29Z","type":"item","id":"Q43584","labels":{"mul":{"language":"mul","value":"4A85.00"},"pt-br":{"language":"pt-br","value":"Doen\u00e7a de hipersensibilidade hep\u00e1tica induzida por droga"},"en":{"language":"en","value":"Drug-induced liver hypersensitivity disease"}},"descriptions":{"pt-br":{"language":"pt-br","value":"Doen\u00e7a de hipersensibilidade hep\u00e1tica induzida por droga \u00e9 uma condi\u00e7\u00e3o, relativamente, rara, mas que pode ter consequ\u00eancias s\u00e9rias para o indiv\u00edduo, a sa\u00fade p\u00fablica, as ag\u00eancias regulat\u00f3rias e a ind\u00fastria farmac\u00eautica. Caracteriza-se pela eleva\u00e7\u00e3o no soro de alanina aminotransferase (ALT), bilirrubina conjugada, ou bilirrubina combinada, ALT e fosfatase alcalina (FA) por > 2 vezes o limite superior do normal; e as drogas mais frequentemente relacionadas s\u00e3o halotano, \u00e1cido tien\u00edlico, di-hidralazina, diclofenaco e carbamazepina."},"en":{"language":"en","value":"Drug-induced liver hypersensitivity disease is a relatively rare condition, but can have serious consequences for the individual patient, public health, regulatory agencies and the pharmaceutical industry. It is characterised by elevation in serum alanine-aminotransferase (ALT), conjugated bilirubin, or combined bilirubin, ALT and alkaline phosphatase (AP) levels > 2 times the upper limit of normal (ULN) and the most frequent related drugs are halothane, tienilic acid, dihydralazine, diclofenac, and carbamazepine."}},"aliases":{},"claims":{"P68":[{"mainsnak":{"snaktype":"value","property":"P68","hash":"1c7459c49cdf8a1a0a34b2e15b4eee9bb4d2e306","datavalue":{"value":"https://id.who.int/icd/entity/674464254","type":"string"},"datatype":"url"},"type":"statement","id":"Q43584$69E20F9D-7C47-485F-AAC9-ADE057CF78EA","rank":"normal"}],"P67":[{"mainsnak":{"snaktype":"value","property":"P67","hash":"601257fc59765dc50bef4a5440cd0144ef4cd218","datavalue":{"value":"CID11:4A85.00","type":"string"},"datatype":"string"},"type":"statement","id":"Q43584$6C4CAA9C-BC61-460A-852C-96D2DED24808","rank":"normal"}],"P70":[{"mainsnak":{"snaktype":"value","property":"P70","hash":"a1e115746646cc0831448a574cc0a153eae33e01","datavalue":{"value":"dki-india-4A85.00","type":"string"},"datatype":"string"},"type":"statement","id":"Q43584$9F4DC7CA-7B2B-4C30-BA74-EDF06E48A2F3","rank":"normal"}],"P86":[{"mainsnak":{"snaktype":"value","property":"P86","hash":"a96031634b9f5dafddaf781bbba3adea6bb64ef4","datavalue":{"value":"Conclu\u00eddo","type":"string"},"datatype":"string"},"type":"statement","id":"Q43584$0CFDCAC2-33FB-4826-BFAE-D279E861DB31","rank":"normal"}],"P78":[{"mainsnak":{"snaktype":"value","property":"P78","hash":"5f9b5be68b7400da549761cf15abfdbc4d1e075b","datavalue":{"value":"https://pauloleads.com.br/cases-publicos/","type":"string"},"datatype":"url"},"type":"statement","id":"Q43584$30A8A750-DE01-4071-B7D9-4E15B66E3458","rank":"normal"}],"P80":[{"mainsnak":{"snaktype":"value","property":"P80","hash":"92b8222fcbb75718504f915073a3f43bd4003d18","datavalue":{"value":{"time":"+2026-08-13T00:00:00Z","timezone":0,"before":0,"after":0,"precision":11,"calendarmodel":"http://www.wikidata.org/entity/Q1985727"},"type":"time"},"datatype":"time"},"type":"statement","id":"Q43584$5A7CCD1B-5C48-4398-85E4-E472E7D27471","rank":"normal"}],"P89":[{"mainsnak":{"snaktype":"value","property":"P89","hash":"51c0fa15556da97b327b5149e9c17f68f426afaa","datavalue":{"value":{"entity-type":"item","numeric-id":19191,"id":"Q19191"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q43584$431C9409-BA23-4C4F-8FB5-42037969169F","rank":"normal"}]},"sitelinks":{}}}}