{"entities":{"Q43138":{"pageid":33506,"ns":120,"title":"Item:Q43138","lastrevid":152348,"modified":"2026-08-13T09:59:42Z","type":"item","id":"Q43138","labels":{"mul":{"language":"mul","value":"DA01.12"},"pt-br":{"language":"pt-br","value":"Estomatite ulcerativa cr\u00f4nica"},"en":{"language":"en","value":"Chronic ulcerative stomatitis"}},"descriptions":{"pt-br":{"language":"pt-br","value":"Estomatite ulcerativa cr\u00f4nica (EUC) \u00e9 uma doen\u00e7a rara que se apresenta com eros\u00f5es e ulcera\u00e7\u00e3o cr\u00f4nicas da mucosa oral semelhantes ao l\u00edquen plano erosivo, mas refrat\u00e1rias \u00e0s terapias padr\u00e3o. Tipicamente afeta mulheres idosas. O diagn\u00f3stico requer a demonstra\u00e7\u00e3o de dep\u00f3sitos perinucleares granulares pontilhados de IgG nas camadas basal e parabasal do epit\u00e9lio oral (antinuclear estratificado espec\u00edfico epitelial ou padr\u00e3o SES-ANA). H\u00e1 evid\u00eancias crescentes de que a EUC \u00e9 uma doen\u00e7a autoimune provocada por anticorpos IgG circulantes dirigidos contra delta-Np63, uma isoforma da fam\u00edlia p53 de fatores de transcri\u00e7\u00e3o nuclear que est\u00e1 presente ao redor dos n\u00facleos de queratin\u00f3citos basais epiteliais orais normais. A EUC normalmente responde a tratamento com hidroxicloroquina."},"en":{"language":"en","value":"Chronic ulcerative stomatitis (CUS) is a rare disease which presents with chronic oral mucosal erosions and ulceration resembling erosive lichen planus but refractory to standard therapies. It typically occurs in older women. Diagnosis requires the demonstration of speckled granular perinuclear IgG deposits in the basal and parabasal layers of oral epithelium (stratified epithelium-specific antinuclear or SES-ANA pattern). There is increasing evidence that CUS is an autoimmune disease provoked by circulating IgG antibodies directed against delta-Np63, an isoform of the p53 family of nuclear transcription factors which is present around the nuclei of normal oral epithelial basal keratinocytes. CUS normally responds to treatment with hydroxychloroquine."}},"aliases":{},"claims":{"P68":[{"mainsnak":{"snaktype":"value","property":"P68","hash":"2ba0c12f9eda739cdd194c6e41bd98848b786b52","datavalue":{"value":"https://id.who.int/icd/entity/153761635","type":"string"},"datatype":"url"},"type":"statement","id":"Q43138$28093A75-AA8D-4AC2-9184-B956987996CE","rank":"normal"}],"P67":[{"mainsnak":{"snaktype":"value","property":"P67","hash":"7313fd06bfa7497e02fa080c932ac10cc55acf50","datavalue":{"value":"CID11:DA01.12","type":"string"},"datatype":"string"},"type":"statement","id":"Q43138$0935F9DF-2E71-4996-BE6A-1E38632D8A43","rank":"normal"}],"P70":[{"mainsnak":{"snaktype":"value","property":"P70","hash":"b818b5077a5e5b36a63160bcd3918cfd7f9ab8ab","datavalue":{"value":"dki-india-DA01.12","type":"string"},"datatype":"string"},"type":"statement","id":"Q43138$1C7D87F4-8D06-42C8-91CA-8B3B147CFD16","rank":"normal"}],"P86":[{"mainsnak":{"snaktype":"value","property":"P86","hash":"a96031634b9f5dafddaf781bbba3adea6bb64ef4","datavalue":{"value":"Conclu\u00eddo","type":"string"},"datatype":"string"},"type":"statement","id":"Q43138$302590E2-CE6E-4A47-B27D-B8099710E5DE","rank":"normal"}],"P78":[{"mainsnak":{"snaktype":"value","property":"P78","hash":"5f9b5be68b7400da549761cf15abfdbc4d1e075b","datavalue":{"value":"https://pauloleads.com.br/cases-publicos/","type":"string"},"datatype":"url"},"type":"statement","id":"Q43138$7392F569-CA16-42D1-B5AB-53A6A49749D1","rank":"normal"}],"P80":[{"mainsnak":{"snaktype":"value","property":"P80","hash":"92b8222fcbb75718504f915073a3f43bd4003d18","datavalue":{"value":{"time":"+2026-08-13T00:00:00Z","timezone":0,"before":0,"after":0,"precision":11,"calendarmodel":"http://www.wikidata.org/entity/Q1985727"},"type":"time"},"datatype":"time"},"type":"statement","id":"Q43138$45803E5A-CFB2-4080-B129-17C5A5A2E04B","rank":"normal"}],"P89":[{"mainsnak":{"snaktype":"value","property":"P89","hash":"42a1a5e66be5c58cebb32d58537234c7d551ee1c","datavalue":{"value":{"entity-type":"item","numeric-id":18931,"id":"Q18931"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q43138$7875BA60-949D-4852-8564-8E5DE47CCC5E","rank":"normal"}]},"sitelinks":{}}}}