{"entities":{"Q43136":{"pageid":33504,"ns":120,"title":"Item:Q43136","lastrevid":152328,"modified":"2026-08-13T09:59:32Z","type":"item","id":"Q43136","labels":{"mul":{"language":"mul","value":"4A43.1"},"pt-br":{"language":"pt-br","value":"Doen\u00e7a de Mikulicz"},"en":{"language":"en","value":"Mikulicz disease"}},"descriptions":{"pt-br":{"language":"pt-br","value":"Doen\u00e7a de Mikulicz \u00e9 um transtorno relatado pela primeira vez por Johann von Mikulicz em 1892 e caracterizado por edema sim\u00e9trico das gl\u00e2ndulas lacrimais, submandibulares e par\u00f3tidas, com infiltra\u00e7\u00e3o maci\u00e7a dessas gl\u00e2ndulas por c\u00e9lulas mononucleares. Autoanticorpos s\u00e9ricos, como anti-Ro/SS-A, s\u00e3o geralmente negativos e a concentra\u00e7\u00e3o s\u00e9rica de IgG4 pode estar aumentada. Ao contr\u00e1rio da doen\u00e7a de Sj\u00f6gren, a doen\u00e7a IgG4-Mikulicz \u00e9 caracterizada pela forma\u00e7\u00e3o de fol\u00edculos linfoides, mas apresenta n\u00edveis mais baixos de infiltra\u00e7\u00e3o linfoc\u00edtica nos ductos salivares, de modo que sua estrutura permanece intacta."},"en":{"language":"en","value":"Mikulicz disease is a disorder first reported by Johann von Mikulicz in 1892 and characterised by symmetrical swelling of the lachrymal, submandibular, and parotid glands, with massive infiltration of these glands by mononuclear cells. Serum autoantibodies, such as anti-Ro/SS-A, are usually negative and serum IgG4 concentration may be increased. Unlike Sj\u00f6gren disease, IgG4-Mikulicz disease is characterised by the formation of lymphoid follicles, but shows lower levels of lymphocytic infiltration into salivary ducts, such that their structure remains intact."}},"aliases":{},"claims":{"P68":[{"mainsnak":{"snaktype":"value","property":"P68","hash":"a1138bc630746a9330b23706fcf91a4df215c3ed","datavalue":{"value":"https://id.who.int/icd/entity/2012865457","type":"string"},"datatype":"url"},"type":"statement","id":"Q43136$B3ADDF3B-8590-4EF6-9431-1FA9982B7B03","rank":"normal"}],"P67":[{"mainsnak":{"snaktype":"value","property":"P67","hash":"dd9dc25f4f1c45eb98567e884943d3065b9a45e8","datavalue":{"value":"CID11:4A43.1","type":"string"},"datatype":"string"},"type":"statement","id":"Q43136$C7BBB1E1-9D51-4430-A3D2-06C0EA654432","rank":"normal"}],"P70":[{"mainsnak":{"snaktype":"value","property":"P70","hash":"556776ebd6d476572bbea1dff5386fb49f0f0437","datavalue":{"value":"dki-india-4A43.1","type":"string"},"datatype":"string"},"type":"statement","id":"Q43136$C9F45445-1C17-48BA-997F-E3CE14E48E25","rank":"normal"}],"P86":[{"mainsnak":{"snaktype":"value","property":"P86","hash":"a96031634b9f5dafddaf781bbba3adea6bb64ef4","datavalue":{"value":"Conclu\u00eddo","type":"string"},"datatype":"string"},"type":"statement","id":"Q43136$A582E01A-60F8-4B84-A30B-05F30E08F57A","rank":"normal"}],"P78":[{"mainsnak":{"snaktype":"value","property":"P78","hash":"5f9b5be68b7400da549761cf15abfdbc4d1e075b","datavalue":{"value":"https://pauloleads.com.br/cases-publicos/","type":"string"},"datatype":"url"},"type":"statement","id":"Q43136$C45C432D-015A-4D8D-B3C4-0D04DD035E96","rank":"normal"}],"P80":[{"mainsnak":{"snaktype":"value","property":"P80","hash":"92b8222fcbb75718504f915073a3f43bd4003d18","datavalue":{"value":{"time":"+2026-08-13T00:00:00Z","timezone":0,"before":0,"after":0,"precision":11,"calendarmodel":"http://www.wikidata.org/entity/Q1985727"},"type":"time"},"datatype":"time"},"type":"statement","id":"Q43136$75549221-46FA-4AFB-B74F-48A93CC241A9","rank":"normal"}],"P89":[{"mainsnak":{"snaktype":"value","property":"P89","hash":"441372279d9e3341a0a315237df4524022517a70","datavalue":{"value":{"entity-type":"item","numeric-id":18927,"id":"Q18927"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q43136$38F86551-0168-4017-8CDA-45DAAA71588C","rank":"normal"}]},"sitelinks":{}}}}