{"entities":{"Q42801":{"pageid":33169,"ns":120,"title":"Item:Q42801","lastrevid":149356,"modified":"2026-08-13T09:29:30Z","type":"item","id":"Q42801","labels":{"mul":{"language":"mul","value":"CA08.0"},"pt-br":{"language":"pt-br","value":"Rinite al\u00e9rgica"},"en":{"language":"en","value":"Allergic rhinitis"}},"descriptions":{"pt-br":{"language":"pt-br","value":"Rinite al\u00e9rgica \u00e9 uma inflama\u00e7\u00e3o de via a\u00e9rea nasal desencadeada por al\u00e9rgenos aos quais o indiv\u00edduo afetado foi previamente sensibilizado. A patog\u00eanese da rinite al\u00e9rgica \u00e9 uma rea\u00e7\u00e3o al\u00e9rgica tipo I na mucosa nasal. Ant\u00edgenos inalados em contato com a mucosa nasal sensibilizada ligam-se a anticorpos IgE nos mast\u00f3citos, que liberam mediadores qu\u00edmicos como histamina e pept\u00eddeos de leucotrienos. Consequentemente, as termina\u00e7\u00f5es nervosas sensitivas e vasos sangu\u00edneos reagem provocando espirros, coriza e obstru\u00e7\u00e3o nasal (fase de resposta imediata). Na fase de resposta tardia, v\u00e1rios mediadores qu\u00edmicos s\u00e3o produzidos pelos mast\u00f3citos, citocinas s\u00e3o produzidas por c\u00e9lulas Th2 e mast\u00f3citos, e quimiocinas s\u00e3o produzidas por c\u00e9lulas epiteliais, pelo endot\u00e9lio vascular e pelos fibr\u00f3citos, respectivamente. Tais transmissores derivados dessas c\u00e9lulas efetivamente induzem a infiltra\u00e7\u00e3o de v\u00e1rios tipos de c\u00e9lulas inflamat\u00f3rias na mucosa nasal. Entre elas, os eosin\u00f3filos ativados s\u00e3o os principais respons\u00e1veis pelo edema e pela hiper-reatividade da mucosa."},"en":{"language":"en","value":"Allergic rhinitis is an inflammation of nasal airway triggered by allergens to which the affected individual has previously been sensitized. Pathogenesis of allergic rhinitis is type I allergy on the nasal mucosa. Antigens inhaled into sensitized nasal mucosa bind to IgE antibodies on mast cells, which release chemical mediators such as histamine and peptide leukotriene. Consequently terminal of sensory neurons and vessels react to induce sneezing, running nose, and stuffy nose (immediate phase reaction). In late phase reaction, various chemical mediators are produced by mast cells, cytokines are produced by Th2 and mast cells, and chemokines are produced by epithelial cells, endothelium of blood vessels, and fibrocytes, respectively. These cell-derived transmitters actually induce various cell types of inflammatory cell infiltration to nasal mucosa. Among them, activated eosinophils is the main player of mucosal swelling and hyperreactivity."}},"aliases":{},"claims":{"P68":[{"mainsnak":{"snaktype":"value","property":"P68","hash":"f592cc5c5d015e509d0669941efecbf104a8aa63","datavalue":{"value":"https://id.who.int/icd/entity/1711769234","type":"string"},"datatype":"url"},"type":"statement","id":"Q42801$CC1C2BB4-55ED-454B-A5F8-BAC5454D8B6C","rank":"normal"}],"P67":[{"mainsnak":{"snaktype":"value","property":"P67","hash":"43d59f7f435e34698eae0e2092652cf80a563381","datavalue":{"value":"CID11:CA08.0","type":"string"},"datatype":"string"},"type":"statement","id":"Q42801$918E87EC-5381-4BAB-A933-6DEA870F8B6A","rank":"normal"}],"P70":[{"mainsnak":{"snaktype":"value","property":"P70","hash":"0f2ce3574b227bc364c0260566c36cbdfc9329cb","datavalue":{"value":"dki-india-CA08.0","type":"string"},"datatype":"string"},"type":"statement","id":"Q42801$4E6C0441-6CD3-4BF1-B3B3-6463D72833C9","rank":"normal"}],"P86":[{"mainsnak":{"snaktype":"value","property":"P86","hash":"a96031634b9f5dafddaf781bbba3adea6bb64ef4","datavalue":{"value":"Conclu\u00eddo","type":"string"},"datatype":"string"},"type":"statement","id":"Q42801$EB95D349-A8A6-4177-89B2-4717F04C07AE","rank":"normal"}],"P78":[{"mainsnak":{"snaktype":"value","property":"P78","hash":"5f9b5be68b7400da549761cf15abfdbc4d1e075b","datavalue":{"value":"https://pauloleads.com.br/cases-publicos/","type":"string"},"datatype":"url"},"type":"statement","id":"Q42801$EAF0CED1-3DF3-4E60-A40C-3746AE232DB3","rank":"normal"}],"P80":[{"mainsnak":{"snaktype":"value","property":"P80","hash":"92b8222fcbb75718504f915073a3f43bd4003d18","datavalue":{"value":{"time":"+2026-08-13T00:00:00Z","timezone":0,"before":0,"after":0,"precision":11,"calendarmodel":"http://www.wikidata.org/entity/Q1985727"},"type":"time"},"datatype":"time"},"type":"statement","id":"Q42801$254FB0B8-AD59-478D-9E8F-68D85433FF68","rank":"normal"}],"P89":[{"mainsnak":{"snaktype":"value","property":"P89","hash":"13435ed960b57c68aca9f8c376e0d233950b2807","datavalue":{"value":{"entity-type":"item","numeric-id":18640,"id":"Q18640"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q42801$A306100C-C799-4157-A7D2-2063951308F5","rank":"normal"}]},"sitelinks":{}}}}