{"entities":{"Q41383":{"pageid":31751,"ns":120,"title":"Item:Q41383","lastrevid":137679,"modified":"2026-08-13T07:32:08Z","type":"item","id":"Q41383","labels":{"mul":{"language":"mul","value":"8C70.40"},"pt-br":{"language":"pt-br","value":"Distrofia muscular de cinturas dominante"},"en":{"language":"en","value":"Dominant limb-girdle muscular dystrophy"}},"descriptions":{"pt-br":{"language":"pt-br","value":"As distrofias musculares de cinturas (DMC) s\u00e3o um grupo de doen\u00e7as gen\u00e9ticas caracterizadas predominantemente por atrofia e fraqueza progressiva dos m\u00fasculos da cintura proximal do membro, incluindo os m\u00fasculos p\u00e9lvicos, do ombro, do bra\u00e7o e da coxa. Os sintomas iniciais geralmente variam desde a primeira inf\u00e2ncia at\u00e9 o final da idade adulta, e a velocidade de progress\u00e3o e distribui\u00e7\u00e3o de fraqueza e debilidade tamb\u00e9m variam consideravelmente entre os indiv\u00edduos e subtipos gen\u00e9ticos. Existem atualmente 8 DMC autoss\u00f4micos dominantes (DMC1), ligados a muta\u00e7\u00f5es gen\u00e9ticas espec\u00edficas. As DMC dominantes s\u00e3o frequentemente al\u00e9licas com outros transtornos cl\u00ednicos, incluindo as miopatias miofibrilares ou cardiomiopatia dilatada."},"en":{"language":"en","value":"The Limb Girdle Muscular Dystrophies (LGMD) are a group of genetic disorders characterised predominantly by progressive wasting and weakness of proximal limb girdle muscles, including pelvic, shoulder, upper arm and thigh muscles. The onset symptoms usually vary from early childhood to late adulthood, and the progression rate and distribution of weakness and wasting also varies considerably among individuals and genetic subtypes. There are currently 8 autosomal dominant LGMDs (LGMD1), linked to specific gene mutations. Dominant LGMDs are often allelic with other clinical disorders, including the myofibrillar myopathies or dilated cardiomyopathy."}},"aliases":{},"claims":{"P68":[{"mainsnak":{"snaktype":"value","property":"P68","hash":"562d4f9c389dab1b43d68dc371b8fbfd2150f794","datavalue":{"value":"https://id.who.int/icd/entity/537908479","type":"string"},"datatype":"url"},"type":"statement","id":"Q41383$4E29C513-0BB0-41D2-A10B-7BA9E56B33C5","rank":"normal"}],"P67":[{"mainsnak":{"snaktype":"value","property":"P67","hash":"3360d1ffec994122c5c11064716b99854e91ccda","datavalue":{"value":"CID11:8C70.40","type":"string"},"datatype":"string"},"type":"statement","id":"Q41383$2C5468AD-2899-4D76-BDF7-A45056AF4D4C","rank":"normal"}],"P70":[{"mainsnak":{"snaktype":"value","property":"P70","hash":"2e4b3916946956341b0eb92f44037d779a853e64","datavalue":{"value":"dki-india-8C70.40","type":"string"},"datatype":"string"},"type":"statement","id":"Q41383$84281BAB-BBE8-4F4D-B570-0F30126F66EA","rank":"normal"}],"P86":[{"mainsnak":{"snaktype":"value","property":"P86","hash":"a96031634b9f5dafddaf781bbba3adea6bb64ef4","datavalue":{"value":"Conclu\u00eddo","type":"string"},"datatype":"string"},"type":"statement","id":"Q41383$67413AF2-7E5B-4428-9ED0-8020C81796C8","rank":"normal"}],"P78":[{"mainsnak":{"snaktype":"value","property":"P78","hash":"5f9b5be68b7400da549761cf15abfdbc4d1e075b","datavalue":{"value":"https://pauloleads.com.br/cases-publicos/","type":"string"},"datatype":"url"},"type":"statement","id":"Q41383$28935044-043D-4A3F-8947-60745A20FBB9","rank":"normal"}],"P80":[{"mainsnak":{"snaktype":"value","property":"P80","hash":"92b8222fcbb75718504f915073a3f43bd4003d18","datavalue":{"value":{"time":"+2026-08-13T00:00:00Z","timezone":0,"before":0,"after":0,"precision":11,"calendarmodel":"http://www.wikidata.org/entity/Q1985727"},"type":"time"},"datatype":"time"},"type":"statement","id":"Q41383$968654B4-1053-489A-B3C1-FC8DC19389F6","rank":"normal"}],"P89":[{"mainsnak":{"snaktype":"value","property":"P89","hash":"49860d10e863610ca7ca5fb30c57a91d25398191","datavalue":{"value":{"entity-type":"item","numeric-id":17301,"id":"Q17301"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q41383$2AD4496E-21A6-45CE-9FE8-E70AEDB53237","rank":"normal"}]},"sitelinks":{}}}}