{"entities":{"Q41168":{"pageid":31536,"ns":120,"title":"Item:Q41168","lastrevid":135793,"modified":"2026-08-13T07:13:49Z","type":"item","id":"Q41168","labels":{"mul":{"language":"mul","value":"8A45.30"},"pt-br":{"language":"pt-br","value":"Transtorno da subst\u00e2ncia branca devido \u00e0 defici\u00eancia de vitamina B12"},"en":{"language":"en","value":"White matter disorder due to vitamin B12 deficiency"}},"descriptions":{"pt-br":{"language":"pt-br","value":"Caracter\u00edsticas neurol\u00f3gicas ocorrem em 40% dos pacientes com defici\u00eancia de vitamina B12. Degenera\u00e7\u00e3o combinada subaguda \u00e9 uma complica\u00e7\u00e3o neurol\u00f3gica revers\u00edvel potencial de defici\u00eancia de vitamina B12. Sintomas desenvolvem de forma insidiosa e as manifesta\u00e7\u00f5es neurop\u00e1ticas incluem parestesia distal, dorm\u00eancia, ataxia de marcha e diminui\u00e7\u00e3o da propriocep\u00e7\u00e3o dos membros inferiores, enquanto componente mielop\u00e1tico leva \u00e0 preju\u00edzo motor vari\u00e1vel devido \u00e0 disfun\u00e7\u00e3o do trato piramidal. Incontin\u00eancia fecal e urin\u00e1ria com impot\u00eancia e hipotens\u00e3o postural podem ocorrer como parte da mielopatia. Manifesta\u00e7\u00f5es centrais incluem confus\u00e3o, depress\u00e3o, alucina\u00e7\u00e3o progressiva e lentifica\u00e7\u00e3o mental. Pode ocorrer e neuropatia \u00f3ptica."},"en":{"language":"en","value":"Neurological features occur in 40% of patients with B12 deficiency. Subacute combined degeneration is a potentially reversible neurological complication of a vitamin B12 deficiency. Symptoms develop insidiously and neuropathic manifestations include progressive paraesthesia distally, numbness, gait ataxia and diminished proprioception in the lower limbs, while the myelopathic component leads to variable motor impairment due to pyramidal tract dysfunction. Incontinence of bowel and bladder with impotence and postural hypotension occur as part of the myelopathy. Central manifestations include confusion, depression, progressive hallucination and mental slowing. There may also be optic neuropathy present."}},"aliases":{},"claims":{"P68":[{"mainsnak":{"snaktype":"value","property":"P68","hash":"37b7c13da1397f76112f383030383b89fa1e7936","datavalue":{"value":"https://id.who.int/icd/entity/785232077","type":"string"},"datatype":"url"},"type":"statement","id":"Q41168$A42A2AB2-E880-44FB-AB19-8BBF913D239E","rank":"normal"}],"P67":[{"mainsnak":{"snaktype":"value","property":"P67","hash":"df66df29a9aca413e60b7787e4febf4a2171e56e","datavalue":{"value":"CID11:8A45.30","type":"string"},"datatype":"string"},"type":"statement","id":"Q41168$96AB784A-B6D7-4A33-985D-09C34A49AD11","rank":"normal"}],"P70":[{"mainsnak":{"snaktype":"value","property":"P70","hash":"fa7e358e9bb3fc4e4c2dde760437aa171975145e","datavalue":{"value":"dki-india-8A45.30","type":"string"},"datatype":"string"},"type":"statement","id":"Q41168$083A3DF0-659A-4CBA-A6EF-EB325B70130A","rank":"normal"}],"P86":[{"mainsnak":{"snaktype":"value","property":"P86","hash":"a96031634b9f5dafddaf781bbba3adea6bb64ef4","datavalue":{"value":"Conclu\u00eddo","type":"string"},"datatype":"string"},"type":"statement","id":"Q41168$C09913A4-310F-4758-82FA-45EA653765F8","rank":"normal"}],"P78":[{"mainsnak":{"snaktype":"value","property":"P78","hash":"5f9b5be68b7400da549761cf15abfdbc4d1e075b","datavalue":{"value":"https://pauloleads.com.br/cases-publicos/","type":"string"},"datatype":"url"},"type":"statement","id":"Q41168$CA0D8CCF-8AB1-42B2-A15D-CCDBC48AC944","rank":"normal"}],"P80":[{"mainsnak":{"snaktype":"value","property":"P80","hash":"92b8222fcbb75718504f915073a3f43bd4003d18","datavalue":{"value":{"time":"+2026-08-13T00:00:00Z","timezone":0,"before":0,"after":0,"precision":11,"calendarmodel":"http://www.wikidata.org/entity/Q1985727"},"type":"time"},"datatype":"time"},"type":"statement","id":"Q41168$E670C547-FE72-4A36-BE23-610B4C39F236","rank":"normal"}],"P89":[{"mainsnak":{"snaktype":"value","property":"P89","hash":"59c997af8db3634f44931de36f20fb046fe2b23b","datavalue":{"value":{"entity-type":"item","numeric-id":41167,"id":"Q41167"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q41168$6DF70CCC-1377-4D74-8B91-488E2766B95E","rank":"normal"}]},"sitelinks":{}}}}