{"entities":{"Q40135":{"pageid":30503,"ns":120,"title":"Item:Q40135","lastrevid":126933,"modified":"2026-08-13T05:49:44Z","type":"item","id":"Q40135","labels":{"mul":{"language":"mul","value":"CA25"},"pt-br":{"language":"pt-br","value":"Fibrose c\u00edstica"},"en":{"language":"en","value":"Cystic fibrosis"}},"descriptions":{"pt-br":{"language":"pt-br","value":"Fibrose c\u00edstica (FC) \u00e9 uma doen\u00e7a gen\u00e9tica caracterizada pela produ\u00e7\u00e3o de suor com alto conte\u00fado de sal e secre\u00e7\u00f5es mucosas com viscosidade anormal. A doen\u00e7a \u00e9 cr\u00f4nica e geralmente progressiva, usualmente com seu in\u00edcio ocorrendo durante a primeira inf\u00e2ncia ou, ocasionalmente, no nascimento (\u00edleo meconial). Praticamente qualquer \u00f3rg\u00e3o interno pode ser afetado, mas as principais manifesta\u00e7\u00f5es dizem respeito ao sistema respirat\u00f3rio (bronquite cr\u00f4nica), p\u00e2ncreas (insufici\u00eancia pancre\u00e1tica, diabetes da adolesc\u00eancia e, ocasionalmente, pancreatite) e, mais raramente, intestino (obstru\u00e7\u00e3o intestinal) e f\u00edgado (cirrose). Os sintomas e sinais habituais de apresenta\u00e7\u00e3o incluem infec\u00e7\u00e3o pulmonar persistente, insufici\u00eancia pancre\u00e1tica e n\u00edveis elevados de cloreto no suor. Muitos paciente, entretanto, mostram sintomas discretos ou at\u00edpicos e cl\u00ednicos devem estar alertas para a possibilidade de FC mesmo quando apenas poucas das manifesta\u00e7\u00f5es habituais est\u00e3o presentes. Para o diagn\u00f3stico da fibrose c\u00edstica devem estar presentes ambos os crit\u00e9rios: sintomas compat\u00edveis com FC em pelo menos um sistema org\u00e2nico e evid\u00eancia de disfun\u00e7\u00e3o do regulador da condut\u00e2ncia transmembrana da fibrose c\u00edstica (CFTR)"},"en":{"language":"en","value":"Cystic fibrosis (CF) is a genetic disorder characterised by the production of sweat with a high salt content and mucus secretions with an abnormal viscosity. The disease is chronic and generally progressive, with onset usually occurring during early childhood or, occasionally, at birth (meconium ileus). Virtually any internal organ may be involved but the principle manifestations concern the breathing apparatus (chronic bronchitis), pancreas (pancreatic insufficiency, adolescent diabetes and occasionally pancreatitis) and, more rarely, the intestine (stercoral obstruction) or liver (cirrhosis). The usual presenting symptoms and signs include persistent pulmonary infection, pancreatic insufficiency, and elevated sweat chloride levels. However, many patients demonstrate mild or atypical symptoms, and clinicians should remain alert to the possibility of CF even when only a few of the usual features are present. Both criteria; clinical symptoms consistent with CF in at least one organ system and evidence of cystic fibrosis transmembrane conductance regulator (CFTR) dysfunction must be met to diagnose cystic fibrosis."}},"aliases":{},"claims":{"P68":[{"mainsnak":{"snaktype":"value","property":"P68","hash":"ac30278a884c448309985b26ad471a3d83bb5f05","datavalue":{"value":"https://id.who.int/icd/entity/514403112","type":"string"},"datatype":"url"},"type":"statement","id":"Q40135$563C3F9E-6AC8-4E08-9332-7733ED996B25","rank":"normal"}],"P67":[{"mainsnak":{"snaktype":"value","property":"P67","hash":"c5426dd54a2f06776a13a8d11dd6bf10a2781333","datavalue":{"value":"CID11:CA25","type":"string"},"datatype":"string"},"type":"statement","id":"Q40135$B63EF942-C697-4924-A56F-8F727F432CB7","rank":"normal"}],"P70":[{"mainsnak":{"snaktype":"value","property":"P70","hash":"6cec0b9a9e2d247d33c9af9a5e9486e3f686d731","datavalue":{"value":"dki-india-CA25","type":"string"},"datatype":"string"},"type":"statement","id":"Q40135$75B6F46C-93CB-4D0D-9B67-61408F46C4AF","rank":"normal"}],"P86":[{"mainsnak":{"snaktype":"value","property":"P86","hash":"a96031634b9f5dafddaf781bbba3adea6bb64ef4","datavalue":{"value":"Conclu\u00eddo","type":"string"},"datatype":"string"},"type":"statement","id":"Q40135$57EF870B-74EF-4C95-B68D-0CA2A4A9482E","rank":"normal"}],"P78":[{"mainsnak":{"snaktype":"value","property":"P78","hash":"5f9b5be68b7400da549761cf15abfdbc4d1e075b","datavalue":{"value":"https://pauloleads.com.br/cases-publicos/","type":"string"},"datatype":"url"},"type":"statement","id":"Q40135$0BF6E486-3ADB-4028-945C-E816E342C462","rank":"normal"}],"P80":[{"mainsnak":{"snaktype":"value","property":"P80","hash":"92b8222fcbb75718504f915073a3f43bd4003d18","datavalue":{"value":{"time":"+2026-08-13T00:00:00Z","timezone":0,"before":0,"after":0,"precision":11,"calendarmodel":"http://www.wikidata.org/entity/Q1985727"},"type":"time"},"datatype":"time"},"type":"statement","id":"Q40135$EF1D4F4A-F049-4F14-BF0C-58A02F6290DF","rank":"normal"}],"P89":[{"mainsnak":{"snaktype":"value","property":"P89","hash":"c902f79b91cd665420cad05c88a7f41271b1e4e3","datavalue":{"value":{"entity-type":"item","numeric-id":15727,"id":"Q15727"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q40135$13264F1B-8130-4B03-9A1C-CB373EBBE265","rank":"normal"}]},"sitelinks":{}}}}