{"entities":{"Q40060":{"pageid":30428,"ns":120,"title":"Item:Q40060","lastrevid":126241,"modified":"2026-08-13T05:43:18Z","type":"item","id":"Q40060","labels":{"mul":{"language":"mul","value":"5C51.20"},"pt-br":{"language":"pt-br","value":"Hiperoxal\u00faria prim\u00e1ria tipo I"},"en":{"language":"en","value":"Primary hyperoxaluria type 1"}},"descriptions":{"pt-br":{"language":"pt-br","value":"A hiperoxal\u00faria tipo 1 \u00e9 devido a um defeito numa enzima hep\u00e1tica peroxissomal alanina glioxilato aminotransferase. A forma infantil \u00e9 caracterizada por insufici\u00eancia renal cr\u00f4nica por deposi\u00e7\u00e3o excessiva de oxalato. Em outros pacientes apresenta-se como urolit\u00edase recidivante , que se deteriora com infec\u00e7\u00f5es, hemat\u00faria, c\u00f3licas nefr\u00e9ticas ou comprometimento renal agudo por obstru\u00e7\u00e3o completa. Doen\u00e7a renal terminal ocorre antes dos 15 anos de idade em metade dos casos e acabam levando a deposi\u00e7\u00e3o de oxalato em outros tecidos, causando defeitos de condu\u00e7\u00e3o card\u00edaca, hipertens\u00e3o, gangrena distal e redu\u00e7\u00e3o da mobilidade e dor articular."},"en":{"language":"en","value":"Primary hyperoxaluria type 1 is a rare metabolic disorder due to a defect of the peroxysomal hepatic enzyme L-alanine: glyoxylate aminotransferase (AGT). The infantile form is characterised by chronic renal failure due to massive oxalate deposition. In other patients, urolithiasis develops with infections, haematuria, renal colic or acute renal failure due to complete obstruction. End-stage renal failure occurs before 15 years of age in half the cases and the resulting increase of circulating oxalate leads to its deposition in tissues causing cardiac conduction defects, hypertension, distal gangrene, and reduced joint mobility and pain."}},"aliases":{},"claims":{"P68":[{"mainsnak":{"snaktype":"value","property":"P68","hash":"29bde0c54b5c413adc8452e5b880fe78805c0877","datavalue":{"value":"https://id.who.int/icd/entity/692812009","type":"string"},"datatype":"url"},"type":"statement","id":"Q40060$D7196CF5-9785-4CA5-9346-0C0C6E599625","rank":"normal"}],"P67":[{"mainsnak":{"snaktype":"value","property":"P67","hash":"baff39f57caeb3f01a22df4379c3b3df8cbe67f7","datavalue":{"value":"CID11:5C51.20","type":"string"},"datatype":"string"},"type":"statement","id":"Q40060$FFD7418F-8EF7-4605-92EA-3AB7CB2D9F1F","rank":"normal"}],"P70":[{"mainsnak":{"snaktype":"value","property":"P70","hash":"c6a85b83b2750e83d37b0c63898e1852ff12da96","datavalue":{"value":"dki-india-5C51.20","type":"string"},"datatype":"string"},"type":"statement","id":"Q40060$622C30D5-FB29-4E4C-9849-FD18ADE008FB","rank":"normal"}],"P86":[{"mainsnak":{"snaktype":"value","property":"P86","hash":"a96031634b9f5dafddaf781bbba3adea6bb64ef4","datavalue":{"value":"Conclu\u00eddo","type":"string"},"datatype":"string"},"type":"statement","id":"Q40060$3D794B66-E7F4-4455-90DC-4BCC5425FA1D","rank":"normal"}],"P78":[{"mainsnak":{"snaktype":"value","property":"P78","hash":"5f9b5be68b7400da549761cf15abfdbc4d1e075b","datavalue":{"value":"https://pauloleads.com.br/cases-publicos/","type":"string"},"datatype":"url"},"type":"statement","id":"Q40060$6CE3D712-9F81-406F-86E5-37B77B3602A3","rank":"normal"}],"P80":[{"mainsnak":{"snaktype":"value","property":"P80","hash":"92b8222fcbb75718504f915073a3f43bd4003d18","datavalue":{"value":{"time":"+2026-08-13T00:00:00Z","timezone":0,"before":0,"after":0,"precision":11,"calendarmodel":"http://www.wikidata.org/entity/Q1985727"},"type":"time"},"datatype":"time"},"type":"statement","id":"Q40060$A656EA05-342F-489C-8A26-4B4539F05E19","rank":"normal"}],"P89":[{"mainsnak":{"snaktype":"value","property":"P89","hash":"74033f520e371031dfe7b2b69678c8e3e3b08de3","datavalue":{"value":{"entity-type":"item","numeric-id":15611,"id":"Q15611"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q40060$B3EB0F9B-7FA0-4DFC-8FC3-8F4E5292AF11","rank":"normal"}]},"sitelinks":{}}}}