{"entities":{"Q39861":{"pageid":30229,"ns":120,"title":"Item:Q39861","lastrevid":124404,"modified":"2026-08-13T05:25:55Z","type":"item","id":"Q39861","labels":{"mul":{"language":"mul","value":"5A71.01"},"pt-br":{"language":"pt-br","value":"Hiperplasia adrenal cong\u00eanita"},"en":{"language":"en","value":"Congenital adrenal hyperplasia"}},"descriptions":{"pt-br":{"language":"pt-br","value":"Hiperplasia adrenal cong\u00eanita (HAC) refere-se a um grupo de condi\u00e7\u00f5es associadas a completa (forma cl\u00e1ssica) ou parcial (n\u00e3o cl\u00e1ssica) anormalidades na bioss\u00edntese dos horm\u00f4nios adrenais. A condi\u00e7\u00e3o \u00e9 caracterizada por produ\u00e7\u00e3o insuficiente de cortisol, ou de aldosterona ( forma cl\u00e1ssica com perda de sal), associada a excesso de produ\u00e7\u00e3o de andr\u00f3genos adrenais. Na forma cl\u00e1ssica, descompensa\u00e7\u00e3o metab\u00f3lica (desidrata\u00e7\u00e3o com hiponatremia, hipercalemia e acidose associada com defici\u00eancia de mineralocorticoide, e hipoglicemia associada com defici\u00eancia de glicocorticoide) pode ser fatal a partir do per\u00edodo neonatal. Varia\u00e7\u00e3o genital pode ser observada ao nascimento em meninas afetadas. Hiperandrogenismo cr\u00f4nico pode levar a acelera\u00e7\u00e3o do crescimento durante a inf\u00e2ncia, mas a matura\u00e7\u00e3o \u00f3ssea avan\u00e7ada pode levar a um d\u00e9ficit na altura final. Adultos tendem a ter sobrepeso e dist\u00farbios metab\u00f3licos, anomalias \u00f3sseas e problemas de fertilidade podem estar presentes. Formas n\u00e3o cl\u00e1ssicas s\u00e3o associadas com in\u00edcio posterior, durante o per\u00edodo peri ou p\u00f3s-puberal e manifestam-se com sinais de hiperandrogenismo (acne, hirsutismo, altera\u00e7\u00f5es menstruais e infertilidade)."},"en":{"language":"en","value":"Congenital adrenal hyperplasia (CAH) refers to a group of conditions associated with either complete (classical form) or partial (non-classical) anomalies in the biosynthesis of adrenal hormones. The condition is characterised by insufficient production of cortisol, or of aldosterone (classical form with salt wasting), associated with overproduction of adrenal androgens. In the classical form, metabolic decompensation (dehydration with hyponatraemia, hyperkalaemia and acidosis associated with mineralocorticoid deficiency, and hypoglycaemia associated with glucocorticoid deficiency) may be life-threatening from the neonatal period onwards. Genital variations may be noted at birth in affected females. Chronic hyperandrogenism may lead to accelerated growth during childhood, but advanced bone maturation may lead to a deficit in final height. Adults tend to be overweight and metabolic disturbances, bone anomalies and fertility problems may also be present. Non-classical forms are associated with later onset, during the peri- or postpubertal period, and manifest with signs of hyperandrogenism (acne, hirsutism, menstrual problems and infertility)."}},"aliases":{},"claims":{"P68":[{"mainsnak":{"snaktype":"value","property":"P68","hash":"9351e8738bb6a4d82530398b2fa11c28778b1e38","datavalue":{"value":"https://id.who.int/icd/entity/172733763","type":"string"},"datatype":"url"},"type":"statement","id":"Q39861$FBA8E7F7-0DCF-403F-AE2F-B214C635469C","rank":"normal"}],"P67":[{"mainsnak":{"snaktype":"value","property":"P67","hash":"d69578e01da47c698b66594bd14f76f462042f9a","datavalue":{"value":"CID11:5A71.01","type":"string"},"datatype":"string"},"type":"statement","id":"Q39861$54067FE2-D2B9-4C89-A053-C98C5AEBAC14","rank":"normal"}],"P70":[{"mainsnak":{"snaktype":"value","property":"P70","hash":"110f92aeeccf1c195abd5d68fe5d860b5c126a89","datavalue":{"value":"dki-india-5A71.01","type":"string"},"datatype":"string"},"type":"statement","id":"Q39861$1CC77497-34C4-42AB-B0F3-E289F3E340AA","rank":"normal"}],"P86":[{"mainsnak":{"snaktype":"value","property":"P86","hash":"a96031634b9f5dafddaf781bbba3adea6bb64ef4","datavalue":{"value":"Conclu\u00eddo","type":"string"},"datatype":"string"},"type":"statement","id":"Q39861$7024B492-5A8E-41F6-B88C-DF13E4D2FB81","rank":"normal"}],"P78":[{"mainsnak":{"snaktype":"value","property":"P78","hash":"5f9b5be68b7400da549761cf15abfdbc4d1e075b","datavalue":{"value":"https://pauloleads.com.br/cases-publicos/","type":"string"},"datatype":"url"},"type":"statement","id":"Q39861$2922EF6A-DA63-4348-A253-1CF43AE59B19","rank":"normal"}],"P80":[{"mainsnak":{"snaktype":"value","property":"P80","hash":"92b8222fcbb75718504f915073a3f43bd4003d18","datavalue":{"value":{"time":"+2026-08-13T00:00:00Z","timezone":0,"before":0,"after":0,"precision":11,"calendarmodel":"http://www.wikidata.org/entity/Q1985727"},"type":"time"},"datatype":"time"},"type":"statement","id":"Q39861$9F8441C6-7560-4521-98CE-E93263DB377C","rank":"normal"}],"P89":[{"mainsnak":{"snaktype":"value","property":"P89","hash":"72a4b9ed02c5a2a36ad5573acfd45b127b0b890f","datavalue":{"value":{"entity-type":"item","numeric-id":15269,"id":"Q15269"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q39861$38FF5925-B452-4639-99C9-9E8208C51CB3","rank":"normal"}]},"sitelinks":{}}}}