{"entities":{"Q39161":{"pageid":29527,"ns":120,"title":"Item:Q39161","lastrevid":118483,"modified":"2026-08-13T04:29:09Z","type":"item","id":"Q39161","labels":{"mul":{"language":"mul","value":"2A82.00"},"pt-br":{"language":"pt-br","value":"Leucemia linfoc\u00edtica cr\u00f4nica de c\u00e9lulas B"},"en":{"language":"en","value":"Chronic lymphocytic leukaemia of B-cell type"}},"descriptions":{"pt-br":{"language":"pt-br","value":"A leucemia linfoc\u00edtica cr\u00f4nica / linfoma linfoc\u00edtico de pequenas c\u00e9lulas (LLC/LLPC) \u00e9 uma neoplasia composta por linf\u00f3citos B monom\u00f3rficos pequenos, arredondados a ligeiramente irregulares no sangue perif\u00e9rico, medula \u00f3ssea, ba\u00e7o e linfonodos, misturados com prolinf\u00f3citos e paraimunoblastos formando centros proliferativos nos infiltrados teciduais. As c\u00e9lulas LLC/LLPC geralmente coexpressam CD5 e CD23. Na aus\u00eancia de envolvimento do tecido extramedular, deve haver linf\u00f3citos monoclonais \u22645x109/L com um fen\u00f3tipo LLC no sangue perif\u00e9rico. O relat\u00f3rio do International Workshop on Chronic Lymphocytic Leukemia (IWCLL) determina que a linfocitose esteja presente por pelo menos 3 meses e tamb\u00e9m permite que o diagn\u00f3stico de CLL seja feito com contagens de linf\u00f3citos mais baixas em pacientes com citopenias ou sintomas relacionados \u00e0 doen\u00e7a. Resta determinar se os pacientes que teriam preenchido os crit\u00e9rios no passado para LLC, mas que atendem aos crit\u00e9rios apenas para linfocitose B monoclonal (LBM), sejam considerados como tendo LLC ou LBM em est\u00e1gio inicial. Alguns podem preferir ainda considerar muitos desses casos mais como LLC. O termo LLPC \u00e9 usado para casos n\u00e3o leuc\u00eamicos com a morfologia do tecido e imunofen\u00f3tipo de LLC. A defini\u00e7\u00e3o IWCLL de LLPC requer linfadenopatia, sem citopenias devido \u00e0 infiltra\u00e7\u00e3o da medula \u00f3ssea por LLC/LLPC e <5x109/L de c\u00e9lulas B no sangue perif\u00e9rico."},"en":{"language":"en","value":"Chronic lymphocytic leukaemia/small lymphocytic lymphoma (CLL/SLL) is a neoplasm composed of monomorphic small, round to slightly irregular B lymphocytes in the peripheral blood (PB), bone marrow (BM), spleen and lymph nodes, admixed with prolymphocytes and paraimmunoblasts forming proliferation centres in tissue infiltrates. The CLL/SLL cells usually coexpress CD5 and CD23. In the absence of extramedullary tissue involvement, there must be <5x109/L monoclonal lymphocytes with a CLL phenotype in the PB. The International Workshop on Chronic Lymphocytic Leukemia (IWCLL) report requires that the lymphocytosis be present for at least 3 months and also allows for the diagnosis of CLL to be made with lower lymphocyte counts in patients with cytopenias or disease-related symptoms. Whether patients who would have fulfilled the criteria in the past for CLL but who fulfill the criteria only for monoclonal B lymphocytosis (MBL) are better considered to have low stage CLL or MBL remains to be determined. Some may prefer to still consider many of these cases more like CLL. The term SLL is used for non-leukaemic cases with the tissue morphology and immunophenotype of CLL. The IWCLL definition of SLL requires lymphadenopathy, no cytopenias due to BM infiltration by CLL/SLL and <5x109/L PB B-cells."}},"aliases":{},"claims":{"P68":[{"mainsnak":{"snaktype":"value","property":"P68","hash":"46649230d34903a94acf07baa3e0d1aec0620221","datavalue":{"value":"https://id.who.int/icd/entity/1726842351","type":"string"},"datatype":"url"},"type":"statement","id":"Q39161$E22D27CE-67C8-4AC5-9266-A12644E2FE1C","rank":"normal"}],"P67":[{"mainsnak":{"snaktype":"value","property":"P67","hash":"fd05e3a3d315ef551dbe39cf49c0f584b68d1c49","datavalue":{"value":"CID11:2A82.00","type":"string"},"datatype":"string"},"type":"statement","id":"Q39161$764853D2-2A3D-4D4F-8C01-E6080AE438BB","rank":"normal"}],"P70":[{"mainsnak":{"snaktype":"value","property":"P70","hash":"8246de3c41b5f7817d56914a9067e254f2ff30c6","datavalue":{"value":"dki-india-2A82.00","type":"string"},"datatype":"string"},"type":"statement","id":"Q39161$D21F3956-D9AE-42B3-9E91-CD06E1A06C4B","rank":"normal"}],"P86":[{"mainsnak":{"snaktype":"value","property":"P86","hash":"a96031634b9f5dafddaf781bbba3adea6bb64ef4","datavalue":{"value":"Conclu\u00eddo","type":"string"},"datatype":"string"},"type":"statement","id":"Q39161$6964F31A-33E7-4323-9D36-3FDC8892253C","rank":"normal"}],"P78":[{"mainsnak":{"snaktype":"value","property":"P78","hash":"5f9b5be68b7400da549761cf15abfdbc4d1e075b","datavalue":{"value":"https://pauloleads.com.br/cases-publicos/","type":"string"},"datatype":"url"},"type":"statement","id":"Q39161$B9EEE9D4-3DE3-4829-9B5F-6BCB91E138D9","rank":"normal"}],"P80":[{"mainsnak":{"snaktype":"value","property":"P80","hash":"92b8222fcbb75718504f915073a3f43bd4003d18","datavalue":{"value":{"time":"+2026-08-13T00:00:00Z","timezone":0,"before":0,"after":0,"precision":11,"calendarmodel":"http://www.wikidata.org/entity/Q1985727"},"type":"time"},"datatype":"time"},"type":"statement","id":"Q39161$5555FA69-B3DC-4AB8-B6BF-303362B4C7BD","rank":"normal"}],"P89":[{"mainsnak":{"snaktype":"value","property":"P89","hash":"231bba07cdb99e93f28076ee1e5a45303cd1ceee","datavalue":{"value":{"entity-type":"item","numeric-id":13846,"id":"Q13846"},"type":"wikibase-entityid"},"datatype":"wikibase-item"},"type":"statement","id":"Q39161$9D57F197-0026-4517-ACA5-1D92B2763F25","rank":"normal"}]},"sitelinks":{}}}}