{"entities":{"Q104255":{"pageid":94653,"ns":120,"title":"Item:Q104255","lastrevid":600673,"modified":"2026-08-17T10:07:14Z","type":"item","id":"Q104255","labels":{"mul":{"language":"mul","value":"ID_1425224652"},"pt-br":{"language":"pt-br","value":"Doen\u00e7a de Charcot-Marie-Tooth tipo 2B"},"en":{"language":"en","value":"Charcot-Marie-Tooth disease type 2B"}},"descriptions":{"pt-br":{"language":"pt-br","value":"A doen\u00e7a de Charcot-Marie-Tooth autoss\u00f4mica dominante tipo 2B (CMT2B) \u00e9 uma forma grave de doen\u00e7a de Charcot-Marie-Tooth axonal, uma neuropatia perif\u00e9rica sensitivomotora. O in\u00edcio do CMT2B, na 2\u00aa ou 3\u00aa d\u00e9cada, \u00e9 caracterizado por ulcera\u00e7\u00f5es e infec\u00e7\u00f5es nos p\u00e9s. A fraqueza sim\u00e9trica e distal se desenvolve principalmente nas pernas, juntamente com uma grave perda sensitiva distal sim\u00e9trica, os reflexos tendinosos est\u00e3o reduzidos apenas nos tornozelos e as deformidades nos p\u00e9s, incluindo p\u00e9s cavos ou planos e dedos em martelo, aparecem na inf\u00e2ncia."},"en":{"language":"en","value":"Autosomal dominant Charcot-Marie-Tooth disease type 2B (CMT2B) is a severe form of axonal Charcot-Marie-Tooth disease, a peripheral sensorimotor neuropathy. CMT2B onset, in the 2nd or 3rd decade, is characterised by ulcerations and infections of feet. Symmetric and distal weakness develops mostly in the legs together with a severe symmetric distal sensory loss, tendon reflexes are only reduced at ankles and foot deformities, including pes cavus or planus and hammer toes, appear in childhood."}},"aliases":{},"claims":{"P68":[{"mainsnak":{"snaktype":"value","property":"P68","hash":"df23b67a4fc5be7d56dc2cfb0fab1fc3211f2807","datavalue":{"value":"https://id.who.int/icd/entity/1425224652","type":"string"},"datatype":"url"},"type":"statement","id":"Q104255$DAAD4F05-F466-4F45-A487-396285EF6CAE","rank":"normal"}],"P67":[{"mainsnak":{"snaktype":"value","property":"P67","hash":"ed0a9283f185f3bbff788e77e74c3f7656ce82f0","datavalue":{"value":"CID11:ID_1425224652","type":"string"},"datatype":"string"},"type":"statement","id":"Q104255$07DE6EE1-8A67-405B-91BE-103A0A045B33","rank":"normal"}],"P70":[{"mainsnak":{"snaktype":"value","property":"P70","hash":"43147c97f243a12aa42e73e5e7b6ad095e595319","datavalue":{"value":"dki-india-ID_1425224652","type":"string"},"datatype":"string"},"type":"statement","id":"Q104255$6802ABC1-EBA2-48B1-B142-8E93828004F0","rank":"normal"}],"P86":[{"mainsnak":{"snaktype":"value","property":"P86","hash":"a96031634b9f5dafddaf781bbba3adea6bb64ef4","datavalue":{"value":"Conclu\u00eddo","type":"string"},"datatype":"string"},"type":"statement","id":"Q104255$4D8F43FE-14E3-4B4A-8D68-3D89AAB4CE4F","rank":"normal"}],"P78":[{"mainsnak":{"snaktype":"value","property":"P78","hash":"5f9b5be68b7400da549761cf15abfdbc4d1e075b","datavalue":{"value":"https://pauloleads.com.br/cases-publicos/","type":"string"},"datatype":"url"},"type":"statement","id":"Q104255$24BB581B-26D8-4A5C-8587-7C2C49D469DF","rank":"normal"}],"P80":[{"mainsnak":{"snaktype":"value","property":"P80","hash":"8612011b2ca718e4ec0db5a49d2de6d25b2e811c","datavalue":{"value":{"time":"+2026-08-16T00:00:00Z","timezone":0,"before":0,"after":0,"precision":11,"calendarmodel":"http://www.wikidata.org/entity/Q1985727"},"type":"time"},"datatype":"time"},"type":"statement","id":"Q104255$3B352898-7715-4EF2-925E-9AB4C7ABD771","rank":"normal"}]},"sitelinks":{}}}}