{"entities":{"Q102307":{"pageid":92700,"ns":120,"title":"Item:Q102307","lastrevid":586619,"modified":"2026-08-16T19:14:46Z","type":"item","id":"Q102307","labels":{"mul":{"language":"mul","value":"ID_1257937011"},"pt-br":{"language":"pt-br","value":"Acidemia succ\u00ednica"},"en":{"language":"en","value":"Succinic acidaemia"}},"descriptions":{"pt-br":{"language":"pt-br","value":"A acidemia succ\u00ednica foi descrita em duas irm\u00e3s (a primeira irm\u00e3 morreu logo ap\u00f3s o nascimento e a outra foi diagnosticado na fase fetal). A primeira irm\u00e3 tamb\u00e9m teve acidose l\u00e1ctica e dificuldade respirat\u00f3ria. Este \u00e9 provavelmente um transtorno autoss\u00f4mico recessivo. A atividade da NADH-citocromo C redutase foi significativamente baixa em ambos os casos e a atividade do NADH-ferricianeto redutase tamb\u00e9m foi baixa no caso fetal, sugerindo uma defici\u00eancia do complexo I do sistema de transporte de el\u00e9trons na membrana mitocondrial."},"en":{"language":"en","value":"Succinic acidemia has been described in two female sibs (the first sib died shortly after birth and the other was diagnosed at the fetal stage). The first sib also had lactic acidosis and respiratory distress. This is presumably an autosomal recessive disorder. NADH-cytochrome C reductase activity was significantly low in both cases and NADH-ferricyanide reductase activity was also low in the fetal case, suggesting a complex I deficiency of the electron transport system in the mitochondrial membrane."}},"aliases":{},"claims":{"P68":[{"mainsnak":{"snaktype":"value","property":"P68","hash":"a9a621caaa0990decd13bf84afc96cbc7a266d07","datavalue":{"value":"https://id.who.int/icd/entity/1257937011","type":"string"},"datatype":"url"},"type":"statement","id":"Q102307$3696A1EC-4A89-4B5A-A298-DD9068A10822","rank":"normal"}],"P67":[{"mainsnak":{"snaktype":"value","property":"P67","hash":"645ef556789084d364d5cca7d11b004ab541f983","datavalue":{"value":"CID11:ID_1257937011","type":"string"},"datatype":"string"},"type":"statement","id":"Q102307$1EA1C4B7-38BC-4B9F-8C51-707D0CD6FAE3","rank":"normal"}],"P70":[{"mainsnak":{"snaktype":"value","property":"P70","hash":"b8f92b20386332ee5f3fd0eb9c63e3dd24f207a0","datavalue":{"value":"dki-india-ID_1257937011","type":"string"},"datatype":"string"},"type":"statement","id":"Q102307$E5593A9A-2AC4-42E1-A797-949D3D360510","rank":"normal"}],"P86":[{"mainsnak":{"snaktype":"value","property":"P86","hash":"a96031634b9f5dafddaf781bbba3adea6bb64ef4","datavalue":{"value":"Conclu\u00eddo","type":"string"},"datatype":"string"},"type":"statement","id":"Q102307$080C6E96-FD19-437F-9F33-75AA59628DC0","rank":"normal"}],"P78":[{"mainsnak":{"snaktype":"value","property":"P78","hash":"5f9b5be68b7400da549761cf15abfdbc4d1e075b","datavalue":{"value":"https://pauloleads.com.br/cases-publicos/","type":"string"},"datatype":"url"},"type":"statement","id":"Q102307$6C680786-4A25-4BD2-8976-6D753C9A5646","rank":"normal"}],"P80":[{"mainsnak":{"snaktype":"value","property":"P80","hash":"378ac503ed43f21e1f461d2823a6ad59da580514","datavalue":{"value":{"time":"+2026-08-15T00:00:00Z","timezone":0,"before":0,"after":0,"precision":11,"calendarmodel":"http://www.wikidata.org/entity/Q1985727"},"type":"time"},"datatype":"time"},"type":"statement","id":"Q102307$C63BED9E-F4FB-47AF-BEFA-1891B5A4E1AF","rank":"normal"}]},"sitelinks":{}}}}