{"entities":{"Q100620":{"pageid":91013,"ns":120,"title":"Item:Q100620","lastrevid":574312,"modified":"2026-08-16T17:21:13Z","type":"item","id":"Q100620","labels":{"mul":{"language":"mul","value":"ID_502185974"},"pt-br":{"language":"pt-br","value":"Transtorno do movimento paraneopl\u00e1sico, autoanticorpo positivo"},"en":{"language":"en","value":"Paraneoplastic movement disorder, autoantibody positive"}},"descriptions":{"pt-br":{"language":"pt-br","value":"Transtorno de movimento paraneopl\u00e1sico soropositivo para autoanticorpos neurais. Quando esses anticorpos neurais t\u00eam como alvo ant\u00edgenos da membrana plasm\u00e1tica, eles s\u00e3o causas de les\u00e3o (por exemplo, receptor de N-metil-D-aspartato associado a teratomas ovarianos) por meio de m\u00faltiplos mecanismos efetores. No entanto, ao alvejar ant\u00edgenos nucleares ou citoplasm\u00e1ticos (por exemplo, colapsina-resposta-mediador-prote\u00edna-5 [CRMP5] cor\u00e9ia paraneopl\u00e1sica associada a c\u00e2ncer de pulm\u00e3o de c\u00e9lulas pequenas e timoma), eles s\u00e3o marcadores de uma les\u00e3o mediada por efetores de c\u00e9lulas T, pois s\u00e3o inacess\u00edveis ao ataque imune in situ, mas os pept\u00eddeos de prote\u00ednas intracelulares s\u00e3o exibidos em mol\u00e9culas de MHC de classe 1 reguladas positivamente em um meio de citocinas pr\u00f3-inflamat\u00f3rias e, em seguida, acess\u00edveis a c\u00e9lulas T citot\u00f3xicas espec\u00edficas de pept\u00eddeos._x000D_ _x000D_ Os autoanticorpos neurais associados incluem:_x000D_ _x000D_ ANNA-2 (anti-Ri) (autoanticorpo nuclear antineuronal tipo 2); CRMP5 (anti-CV2) (prote\u00edna 5 do mediador da resposta da colapsina); GABABR (autoanticorpos de \u00e1cido gama-aminobut\u00edrico); NMDA-R (autoanticorpos para o receptor de N-metil-D-aspartato); Ma2;"},"en":{"language":"en","value":"Paraneoplastic movement disorder seropositive for neural autoantibodies. When these neural antibodies target plasma membrane antigens they are causes of injury (e.g. N-methyl-D-aspartate receptor associated with ovarian teratomas) through multiple effector mechanisms. However, when targeting nuclear or cytoplasmic antigens (e.g. collapsin-response-mediator-protein-5 [CRMP5] paraneoplastic chorea associated with and small-cell lung cancer and thymoma) they are markers of a T-cell effector mediated injury as they are inaccessible to immune attack in situ, but peptides from intracellular proteins are displayed on upregulated MHC class 1 molecules in a pro-inflammatory cytokine milieu and then accessible to peptide specific cytotoxic T-cells.  Associated neural autoantibodies include: ANNA-2(anti-Ri) (antineuronal nuclear autoantibody type 2); CRMP5(anti-CV2) (collapsin response mediator protein 5); GABABR (Gamma-aminobutyric-acid autoantibodies); NMDA-R (N-methyl-D-aspartate receptor autoantibodies); Ma2;"}},"aliases":{},"claims":{"P68":[{"mainsnak":{"snaktype":"value","property":"P68","hash":"3d0c9d1da32d96e935cdb053d14c096ca15f2263","datavalue":{"value":"https://id.who.int/icd/entity/502185974","type":"string"},"datatype":"url"},"type":"statement","id":"Q100620$F81A4857-360F-4C31-A9BD-34949F04C248","rank":"normal"}],"P67":[{"mainsnak":{"snaktype":"value","property":"P67","hash":"a5fdbd6df9f2474b58a72efdb7330ff4d23ef621","datavalue":{"value":"CID11:ID_502185974","type":"string"},"datatype":"string"},"type":"statement","id":"Q100620$362AAB25-0B5F-4939-8FC8-4C2469DE4244","rank":"normal"}],"P70":[{"mainsnak":{"snaktype":"value","property":"P70","hash":"0e7090c173fabedd8fcff6b57fd2836f866fd136","datavalue":{"value":"dki-india-ID_502185974","type":"string"},"datatype":"string"},"type":"statement","id":"Q100620$3AF8C524-7B47-452C-96BB-2131F6411F78","rank":"normal"}],"P86":[{"mainsnak":{"snaktype":"value","property":"P86","hash":"a96031634b9f5dafddaf781bbba3adea6bb64ef4","datavalue":{"value":"Conclu\u00eddo","type":"string"},"datatype":"string"},"type":"statement","id":"Q100620$DE43B315-27C9-45C4-A7B0-DEB60AC08C23","rank":"normal"}],"P78":[{"mainsnak":{"snaktype":"value","property":"P78","hash":"5f9b5be68b7400da549761cf15abfdbc4d1e075b","datavalue":{"value":"https://pauloleads.com.br/cases-publicos/","type":"string"},"datatype":"url"},"type":"statement","id":"Q100620$6FDB7F8B-6D8E-4A16-A677-0DE892AA314E","rank":"normal"}],"P80":[{"mainsnak":{"snaktype":"value","property":"P80","hash":"378ac503ed43f21e1f461d2823a6ad59da580514","datavalue":{"value":{"time":"+2026-08-15T00:00:00Z","timezone":0,"before":0,"after":0,"precision":11,"calendarmodel":"http://www.wikidata.org/entity/Q1985727"},"type":"time"},"datatype":"time"},"type":"statement","id":"Q100620$2FF0EDC2-6BDA-4D9A-939A-1AF2728533F7","rank":"normal"}]},"sitelinks":{}}}}