{"entities":{"Q100614":{"pageid":91007,"ns":120,"title":"Item:Q100614","lastrevid":574266,"modified":"2026-08-16T17:20:46Z","type":"item","id":"Q100614","labels":{"mul":{"language":"mul","value":"ID_1358085002"},"pt-br":{"language":"pt-br","value":"Doen\u00e7a de von Willebrand tipo 2M"},"en":{"language":"en","value":"Von Willebrand disease type 2M"}},"descriptions":{"pt-br":{"language":"pt-br","value":"A doen\u00e7a de von Willebrand tipo 2M (DVW tipo 2M) \u00e9 um subtipo de DVW tipo 2 caracterizada por um transtorno hemorr\u00e1gico associado a uma redu\u00e7\u00e3o da afinidade do fator de von Willebrand (FVW) pelas plaquetas e pelo subendot\u00e9lio na aus\u00eancia de qualquer defici\u00eancia de mult\u00edmeros de FVW de alto peso molecular. A doen\u00e7a manifesta-se anomalias do sangramento mucocut\u00e2neo (menorragia, epistaxe, hemorragia gastrointestinal, etc.). A DVW tipo 2M \u00e9 causada por muta\u00e7\u00f5es no gene do FVW, e a heran\u00e7a \u00e9 autoss\u00f4mica dominante."},"en":{"language":"en","value":"Type 2M von Willebrand disease (type 2M VWD) is a subtype of type 2 VWD (see this term) characterised by a bleeding disorder associated with a decrease in the affinity of the Willebrand factor (von Willebrand factor; VWF) for platelets and the subendothelium in the absence of any deficiency of high molecular weight VWF multimers. The disease manifests as mucocutaneous bleeding anomalies (menorrhagia, epistaxis, gastrointestinal haemorrhage etc.). Type 2M VWD is caused by mutations in the VWF gene and transmission is autosomal dominant."}},"aliases":{},"claims":{"P68":[{"mainsnak":{"snaktype":"value","property":"P68","hash":"24b856de99c56b9d6026b95961bec0eee2cba102","datavalue":{"value":"https://id.who.int/icd/entity/1358085002","type":"string"},"datatype":"url"},"type":"statement","id":"Q100614$F7415B43-16BD-4FCE-8F0E-550FA8E70C8F","rank":"normal"}],"P67":[{"mainsnak":{"snaktype":"value","property":"P67","hash":"eb74828abca00e31a0a70086ef621d00c1f66fe1","datavalue":{"value":"CID11:ID_1358085002","type":"string"},"datatype":"string"},"type":"statement","id":"Q100614$BC12F6EE-69A7-43D7-B2E5-22E2E7F20970","rank":"normal"}],"P70":[{"mainsnak":{"snaktype":"value","property":"P70","hash":"1df6a953afe76912616de3e0c4af113ae6aace6d","datavalue":{"value":"dki-india-ID_1358085002","type":"string"},"datatype":"string"},"type":"statement","id":"Q100614$12838136-DBE9-408A-91A8-8DABD9A4DD0E","rank":"normal"}],"P86":[{"mainsnak":{"snaktype":"value","property":"P86","hash":"a96031634b9f5dafddaf781bbba3adea6bb64ef4","datavalue":{"value":"Conclu\u00eddo","type":"string"},"datatype":"string"},"type":"statement","id":"Q100614$465C48B2-16B8-4EB5-A7EA-42C35AFAC4A8","rank":"normal"}],"P78":[{"mainsnak":{"snaktype":"value","property":"P78","hash":"5f9b5be68b7400da549761cf15abfdbc4d1e075b","datavalue":{"value":"https://pauloleads.com.br/cases-publicos/","type":"string"},"datatype":"url"},"type":"statement","id":"Q100614$0EF56596-04BE-40D8-B363-FF175D90653D","rank":"normal"}],"P80":[{"mainsnak":{"snaktype":"value","property":"P80","hash":"378ac503ed43f21e1f461d2823a6ad59da580514","datavalue":{"value":{"time":"+2026-08-15T00:00:00Z","timezone":0,"before":0,"after":0,"precision":11,"calendarmodel":"http://www.wikidata.org/entity/Q1985727"},"type":"time"},"datatype":"time"},"type":"statement","id":"Q100614$B8183F88-CE6A-409B-A9CB-0F5DA85221CA","rank":"normal"}]},"sitelinks":{}}}}