{"entities":{"Q100581":{"pageid":90974,"ns":120,"title":"Item:Q100581","lastrevid":574016,"modified":"2026-08-16T17:18:23Z","type":"item","id":"Q100581","labels":{"mul":{"language":"mul","value":"ID_1906394190"},"pt-br":{"language":"pt-br","value":"Mioclonia paraneopl\u00e1sica"},"en":{"language":"en","value":"Paraneoplastic myoclonus"}},"descriptions":{"pt-br":{"language":"pt-br","value":"Mioclonia paraneopl\u00e1sica pode ocorrer no contexto de um c\u00e2ncer sem opsocl\u00f4nus e pode ser tanto um componente de uma apresenta\u00e7\u00e3o neurol\u00f3gica multifocal (p.ex. na encefalopatia autoimune) quanto ocorrer isoladamente. Os espasmos miocl\u00f4nicos podem ser focais ou em todo o corpo e podem ser confundidos com tremor. Autoanticorpos neuronais concomitantes podem ser encontrados (p.ex. IgG contra prote\u00edna mediadora de resposta \u00e0 colapsina 5) e \u00e9 apropriado rastrear de um c\u00e2ncer subjacente, mas tamb\u00e9m \u00e9 importante excluir outras patologias potenciais (p.ex. miocl\u00f4nus induzido por drogas). _x000D_ Autoanticorpos associados:_x000D_ AMPA-R (anticorpo contra receptor de \u00e1cido amino-3-hidroxi-5-metil-4-isoxazolepropi\u00f4nico); anfifisina; ANNA-1 (anti-Hu) (autoanticorpo nuclear antineuronal tipo 1); ANNA-2 (anti-Ri) (autoanticorpo nuclear antineuronal tipo 2); ANNA-3 (autoanticorpo nuclear antineuronal tipo 3); CRMP5(anti-CV2) (prote\u00edna mediadora de resposta \u00e0 colapsina 5); GABABR (autoanticorpos contra receptores GABA tipo B); Ma1; Ma2; mGluR5 (anticorpo contra receptor de glutamato metabotr\u00f3pico tipo 5); NMDA-R (autoanticorpos contra receptor de N-metil-D-aspartato); PCA-2 (autoanticorpo citoplasm\u00e1tico contra c\u00e9lulas de Purkinje tipo 2); PCA-Tr (anticorpo contra c\u00e9lulas de Purkinje Tr);"},"en":{"language":"en","value":"Paraneoplastic myoclonus may occur in the setting of cancer without opsoclonus and be either a component of a multifocal neurological presentation (e.g. in autoimmune encephalopathy) or occur in isolation. The myoclonic jerks may be focal or whole body and may be mistaken for tremor. Accompanying neural autoantibodies may be found (e.g. collapsing response mediator protein 5-IgG) and screening for an underlying cancer is appropriate, but it is also important to exclude other potential etiologies (e.g. drug induced myoclonus).  Associated autoantibodies: AMPA-R (amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor antibodies); amphiphysin; ANNA-1(anti-Hu) (antineuronal nuclear autoantibody type 1); ANNA-2(anti-Ri) (antineuronal nuclear autoantibody type 2); ANNA-3 (antineuronal nuclear autoantibody type 3); CRMP5(anti-CV2) (collapsin response mediator protein 5); GABABR (Gamma-aminobutyric-acid type-B autoantibodies); Ma1; Ma2; mGluR5 (metabotropic glutamate receptor antibody type 5); NMDA-R (N-methyl-D-aspartate receptor autoantibodies); PCA-2 (purkinje cell cytoplasmic autoantibody type 2); PCA-Tr (purkinje cell autoantibody-Tr);"}},"aliases":{},"claims":{"P68":[{"mainsnak":{"snaktype":"value","property":"P68","hash":"d395969b2cf7218547acc9968dc7d78f42d09ef9","datavalue":{"value":"https://id.who.int/icd/entity/1906394190","type":"string"},"datatype":"url"},"type":"statement","id":"Q100581$B51B2AB8-A9A0-4544-B94D-92FA87C9C614","rank":"normal"}],"P67":[{"mainsnak":{"snaktype":"value","property":"P67","hash":"25243c1706285855616f0e5fb9f51cd65dd80b8e","datavalue":{"value":"CID11:ID_1906394190","type":"string"},"datatype":"string"},"type":"statement","id":"Q100581$BCFF797E-3A98-4091-B826-7F948E7A2850","rank":"normal"}],"P70":[{"mainsnak":{"snaktype":"value","property":"P70","hash":"612ce87e13c50ce9d004d751c94da87c05f64696","datavalue":{"value":"dki-india-ID_1906394190","type":"string"},"datatype":"string"},"type":"statement","id":"Q100581$31D74CAF-5561-4BC3-AB56-AA81C015CA11","rank":"normal"}],"P86":[{"mainsnak":{"snaktype":"value","property":"P86","hash":"a96031634b9f5dafddaf781bbba3adea6bb64ef4","datavalue":{"value":"Conclu\u00eddo","type":"string"},"datatype":"string"},"type":"statement","id":"Q100581$0CF71AEE-751B-44DD-AE0D-0BF616D24044","rank":"normal"}],"P78":[{"mainsnak":{"snaktype":"value","property":"P78","hash":"5f9b5be68b7400da549761cf15abfdbc4d1e075b","datavalue":{"value":"https://pauloleads.com.br/cases-publicos/","type":"string"},"datatype":"url"},"type":"statement","id":"Q100581$89D4D106-841D-4F25-AFD2-AF7D198B7FCA","rank":"normal"}],"P80":[{"mainsnak":{"snaktype":"value","property":"P80","hash":"378ac503ed43f21e1f461d2823a6ad59da580514","datavalue":{"value":{"time":"+2026-08-15T00:00:00Z","timezone":0,"before":0,"after":0,"precision":11,"calendarmodel":"http://www.wikidata.org/entity/Q1985727"},"type":"time"},"datatype":"time"},"type":"statement","id":"Q100581$7CAD556B-AB6F-4A25-BDE9-17B7C844B036","rank":"normal"}]},"sitelinks":{}}}}