Von Willebrand disease type 2N (Q100619)

Type 2N von Willebrand disease (type 2N VWD) is a subtype of type 2 VWD characterised by a bleeding disorder associated with a marked decrease in the affinity of the Willebrand factor (von Willebrand factor; VWF) for factor VIII (FVIII). Abnormal bleeding manifestations are much less frequent in this VWD subtype than in other forms of the disease.