Trichodysplasia spinulosa (Q96362)

Trichodysplasia spinulosa is a folliculocentric cutaneous viral infection of immunosuppressed patients which causes abnormal hair follicle maturation. It has been linked to the presence of papilloma or polyoma virus particles within follicular keratinocytes. Histopathology shows abnormal follicle maturation, excessive production of inner root sheath epithelium and hyperkeratosis of the infundibulum. The condition presents with widespread follicular papules with a central keratin spicule. The face is nearly always involved. It has been reported in transplant patients and following chemotherapy for leukaemia.