POEMS syndrome (Q94853)

POEMS syndrome is defined by the presence of a peripheral neuropathy (P), a monoclonal plasma cell disorder (M), and other paraneoplastic features, the most common of which are organomegaly (O), endocrinopathy (E), skin changes (S), papilledema, edema, effusions, ascites, and thrombocytosis. Virtually all patients will have either at least one sclerotic bone lesion or concomitant Castleman disease. Associated neural autoantibodies are: Immunoglobulin G or Immunoglobulin A with lambda light chain, increased Vascular Endothelial Growth Factor (VEGF).