Cutaneous microvascular occlusion due to systemic coagulopathies (Q91533)

Purpura and cutaneous infarction resulting from systemic coagulation disturbances, particularly of the thrombomodulin–protein C/S anticoagulant pathway. Thrombosis may be largely limited to the skin (coumadin necrosis) but cutaneous signs may presage fulminant sepsis as in disseminated intravascular coagulation secondary to meningococcal septicaemia.