Myasthenia gravis, seronegative (Q88656)
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In approximately 50% of the Acetylcholine receptor-seronegative patients with generalised Myasthenia Gravis (MG), no autoantibodies against Muscle-specific kinase (MuSK) or against AChRs could be detected by routine methods. In this group autoantibodies against the low-density lipoprotein receptor-related protein 4 (LRP4) have been identified in several dSN-MG sera with a frequency variation (7-32%). There are also double positive patients (with LRP4 and AChR or MuSK). Anti-agrin antibodies were detected in combination with autoantibodies against MuSK, LRP4, or AChRs in 10-15% of the generalised MG patients.
| Language | Label | Description | Also known as |
|---|---|---|---|
| default for all languages | ID_1979177138 |
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| English | Myasthenia gravis, seronegative |
In approximately 50% of the Acetylcholine receptor-seronegative patients with generalised Myasthenia Gravis (MG), no autoantibodies against Muscle-specific kinase (MuSK) or against AChRs could be detected by routine methods. In this group autoantibodies against the low-density lipoprotein receptor-related protein 4 (LRP4) have been identified in several dSN-MG sera with a frequency variation (7-32%). There are also double positive patients (with LRP4 and AChR or MuSK). Anti-agrin antibodies were detected in combination with autoantibodies against MuSK, LRP4, or AChRs in 10-15% of the generalised MG patients. |
