Myasthenia gravis, autoimmune acquired (Q88653)

Acquired myasthenia gravis is an autoimmune disorder of the neuromuscular junction characterised by fluctuating muscular weakness that often affects selected muscle groups preferentially. The pathophysiological result is muscle endplate dysfunction and consequent fatigable weakness. Subtypes are broadly classified as: early-onset myasthenia gravis (<50 years); late-onset myasthenia gravis (>50 years); thymoma-associated myasthenia gravis; myasthenia gravis with anti-muscle-specific receptor tyrosine kinase antibodies; ocular myasthenia gravis; myasthenia gravis with no detectable antibodies.