Transient congenital hypothyroidism due to transplacental passage of maternal TSH receptor blocking antibodies (Q86204)

Transient congenital hypothyroidism can result from transplacental passage of maternal TSH-binding inhibitory antibodies. This occurs in mothers with autoimmune thyroiditis where immunoglobulin G (IgG) antithyroid antibodies are transmitted across the placenta and block TSH binding sites on the fetal thyroid. This form of congenital hypothyroidism generally resolves within the first 2 to 3 months of life.