Keratolytic winter erythema (Q85682)

Keratolytic winter erythema is an autosomal dominant disorder first described in inhabitants of the province of Oudtshoorn in South Africa. It consists in intermittent and recurrent centrifugal peeling and erythema of the palms and soles, though it may extend up the limbs to the buttocks and the trunk. The age of onset varies from infancy to early adulthood after which it tends to become less pronounced. A striking feature is the onset and recurrence with cold winter weather. The genetic basis is not understood as yet.