Pseudopolyneuritic form of Amyotrophic lateral sclerosis (Q85578)

Pseudopolyneuritic form of amyotrophic lateral sclerosis (ALS) is an uncommon variant of ALS presenting with foot drop and weakness of muscles of the anterior compartment. It may be unilateral or bilateral and exists without sensory changes. The disorder mimics a peripheral neuropathy. Multifocal motor neuropathy, distal spinal muscular atrophy, and lumbosacral radiculopathy should be considered in the differential diagnosis. Upper motor neuron signs and bulbar involvement are minimal or absent in the pseudopolyneuritic form of ALS, but may appear in later stage of the disorder.