Certain specified neurological disorder aquaporin-4 antibody positive (Q84139)
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Since discovery of the neural autoantibody to aquaporin-4 (AQP4-IgG) as a biomarker of neuromyelitis optica a wider spectrum of neurological disease associated with AQP4-IgG seropositivity is recognised and often referred to as NMO spectrum disorders (see NMO spectrum disorders [NMOSD] definition), but may be categorized under this heading emphasizing disease outside the optic nerves and spinal cord. This includes nausea/vomiting attacks from area postrema lesions, syndrome of inappropriate anti-diuretic-hormone secretion (SIADH) or narcolepsy from hypothalamic lesions, posterior reversible encephalopathy syndrome (PRES) or acute disseminated encephalomyelitis (ADEM) like presentations from cerebral involvement and myositis from muscle involvement.
| Language | Label | Description | Also known as |
|---|---|---|---|
| default for all languages | ID_31533652 |
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| English | Certain specified neurological disorder aquaporin-4 antibody positive |
Since discovery of the neural autoantibody to aquaporin-4 (AQP4-IgG) as a biomarker of neuromyelitis optica a wider spectrum of neurological disease associated with AQP4-IgG seropositivity is recognised and often referred to as NMO spectrum disorders (see NMO spectrum disorders [NMOSD] definition), but may be categorized under this heading emphasizing disease outside the optic nerves and spinal cord. This includes nausea/vomiting attacks from area postrema lesions, syndrome of inappropriate anti-diuretic-hormone secretion (SIADH) or narcolepsy from hypothalamic lesions, posterior reversible encephalopathy syndrome (PRES) or acute disseminated encephalomyelitis (ADEM) like presentations from cerebral involvement and myositis from muscle involvement. |
