Zunich-Kaye syndrome (Q83138)

Zunich-Kaye syndrome is characterised by early-onset migratory ichthyosiform dermatosis, bilateral ocular coloboma, conductive hearing loss, seizures, intellectual deficit, and characteristic facial features: brachycephaly, mild upslanting of the palpebral fissures, pale blue irides, hypertelorism, flat midface and philtrum, anteverted nostrils, thin upper lip and excessive creases around a wide mouth. The acronym CHIME was proposed for the Zunich-Kaye syndrome: Colobomas of the eye, Heart defects, Ichthyosiform dermatosis, Mental retardation, and Ear defects or Epilepsy.