Haff disease (Q67568)

Haff disease is an uncommon syndrome characterized by intense myalgia and rhabdomyolysis, which manifests within 24 h after consuming some types of freshwater or saltwater fish and crustaceans. The implicated cause is believed to be a heat-stable toxin. Myalgia associated with Haff disease can manifest as severe, moderate, or mild discomfort, affecting muscles in various areas such as the back, shoulders, neck, chest, upper and lower limbs. The intensity of muscle pain correlates directly with the estimated weight of the consumed fish. Nevertheless, clinical presentation may show symptoms indicative of multi-organ involvement. Individual susceptibility varies, and some individuals may remain asymptomatic even after sharing the same seafood meal as those affected.