Necrotising polymyositis (Q90737)

Necrotising polymyositis is an immune inflammatory muscle disorders characterised by high CK level, moderate to severe muscle weakness of acute or subacute onset and with histological features of muscle fibre necrosis mediated by macrophages as the main effector cell. There are no T cell infiltrates or MHC-I expression. However, some patients have antibodies against signal recognition particles (SRP). The disease is multifactorial: cancer, viral infection, use of statins, exposure to toxic agents, or underlying autoimmune process; others have no other disease or apparent exposure to exogenous agents.