Paraneoplastic acanthosis nigricans (Q55179)

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Paraneoplastic acanthosis nigricans is thought to be due to production by the associated malignant tumour of factors which stimulate epidermal keratinocyte and dermal fibroblast proliferation. It is most commonly linked to underlying gastro-intestinal malignancy. In a third of cases it precedes the diagnosis of cancer. In contrast with benign acanthosis nigricans it often involves the extremities (tripe palms) and oral cavity.
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    Paraneoplastic acanthosis nigricans
    Paraneoplastic acanthosis nigricans is thought to be due to production by the associated malignant tumour of factors which stimulate epidermal keratinocyte and dermal fibroblast proliferation. It is most commonly linked to underlying gastro-intestinal malignancy. In a third of cases it precedes the diagnosis of cancer. In contrast with benign acanthosis nigricans it often involves the extremities (tripe palms) and oral cavity.

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