Familial restrictive cardiomyopathy due to MYBPC3 gene mutation (Q106235)

Familial restrictive cardiomyopathy due to MYBPC3 (Myosin Binding Protein C3) gene mutation is a type of sarcomeric restrictive cardiomyopathy and is the presence of restrictive cardiomyopathy in the presence of a MYBPC3 gene mutation that is known to be significantly associated with restrictive physiology. Additional information. This disruption in the binding of domains within the contractile apparatus of the myocyte is believed to increase calcium sensitivity of contraction and to impair relaxation.