Chronic painful polyneuropathy associated with diabetes mellitus (Q105581)

Chronic pain may occur in polyneuropathy in type 1 or type 2 diabetes mellitus. Pain may be the initial symptom of a neuropathy or develop over the course of the disease. The pain may be spontaneous or evoked, as an increased response to a painful stimulus (hyperalgesia) or a painful response to a normally nonpainful stimulus (allodynia). Negative (e.g., decreased or loss of sensation) and positive sensory symptoms or signs (e.g., allodynia or hyperalgesia) must be compatible with the anatomical distribution pattern of the polyneuropathy.