Punctate keratoderma of the palmar creases (Q104960)

A common asymptomatic autosomal dominant condition affecting the palms principally of people of African descent. It is characterised by punctate keratotic plugs and pits, generally no more than 1-2 mm in diameter, confined to the creases of the palms and the palmar surfaces of the fingers. The keratotic plugs have been shown to occur directly above the acrosyringium of eccrine sweat ducts. Pits develop when the keratin plugs detach.