Voltage-gated calcium channel-associated Lambert-Eaton myasthenic syndrome (Q96654)

Lambert-Eaton myasthenic syndrome is a rare human autoimmune disorder of the neuromuscular junction caused by the presence of antibodies directed against voltage-gated calcium channels localised in the presynaptic membrane of their motor nerve terminals, thus leading to reduced neuromuscular transmission. In approximately 50% of the patients, Lambert-Eaton myasthenic syndrome is reflected by a paraneoplastic manifestation and most commonly associated with a small cell lung carcinoma whose cells also express voltage-gated calcium channels in their plasma membrane.