Neutrophilic eccrine hidradenitis (Q90164)

Neutrophilic eccrine hidradenitis is an uncommon cutaneous eruption condition characterised histologically by necrosis of the eccrine epithelium and eccrine secretory coil with a dense surrounding neutrophilic infiltrate. The typical clinical presentation is of solitary or disseminated purpuric macules, nodules or plaques arising on the limbs, neck, face and ears 8–10 days after the start of chemotherapy for malignancy, especially acute myeloid leukaemia. It is often associated with fever and may on occasion simulate bacterial cellulitis. Although most commonly associated with chemotherapy, it has been reported in association with infections in immunodeficient hosts and as a paraneoplastic phenomenon.