Thymoma-associated myasthenia gravis (Q88649)

In about 15% of the Acetylcholine receptor (AChR) positive Myasthenia Gravis patients, most common in 4th to 6th decades, the disease can be classified as paraneoplastic, usually associated with a thymoma. Thymoma with MG is equally or less malignant than that without MG. Anti-striational antibodies including anti-titin, ryanodine receptor (RyR), and Kv1.4 antibodies are more frequently found in thymoma-associated MG. In Muscle-specific kinase (MuSK) MG thymoma is rare, albeit small thymomas have been reported.