Myasthenia gravis, other antibodies positive (Q88647)

Late-onset generalised Myasthenia Gravis (MG), either male or female, is associated with atrophic thymuses. Most late-onset (>50 years) patients, either male or female, are AChR positive and in addition often have anti-striational antibodies including anti-titin, ryanodine receptor (RyR), and Kv1.4 antibodies. These antibodies are associated with a severe form of MG and are more frequently found in thymoma-associated MG.