Tarsal-carpal coalition syndrome (Q88630)

Tarsal-carpal coalition syndrome is characterised by fusion of the carpals, tarsals, and phalanges. At birth, patients present with stiffness of the proximal interphalangeal joint of the fifth digit, with or without bony synostosis. Proximo-distal progression leads to involvement of the fourth, third and then the second digits. Other anomalies include brachydactyly, humeroradial synostoses and, in some cases, short stature. Tarsal-carpal coalition syndrome can be distinguished from multiple synostoses syndrome and proximal symphalangism by the absence of hearing loss.