Classic Bartter syndrome (Q85244)

This is a rare inherited defect in the thick ascending limb of the loop of Henle. It is characterised by low potassium levels (hypokalaemia), increased blood pH (alkalosis), and normal to low blood pressure. There are two types of Bartter syndrome: neonatal and classic. A closely associated disorder, Gitelman syndrome, is milder than both subtypes of Bartter syndrome.