Necrolytic migratory erythema (Q68430)

Necrolytic migratory erythema is a rare dermatosis closely associated with an underlying glucagon-secreting tumour of pancreatic islet cells (glucagonoma). It may present clinically with recent onset diabetes mellitus, weight loss and glossitis. Skin and mucous membranes are affected with painful migratory erythematous polycyclic patches or plaques with superficial pustules, vesicles, or bullae. The lesions are typically widespread, but they are accentuated in the intertriginous areas, lower abdomen, and proximal parts of the lower extremities. Lesions begin as erythematous papules; coalesce into patches or plaques; evolve into vesicles, flaccid bullae, and pustules; and then become eroded and crusted.