Paraneoplastic myelopathy, neural autoantibody positive (Q100600): Difference between revisions

Paraneoplastic myelopathy seropositive for neural autoantibodies. When these neural antibodies target plasma membrane antigens they are effectors of injury (e.g. neuromyelitis optica, which may rarely present as a paraneoplastic phenomenon with aquaporin-4 antibody seropositivity) through multiple effector mechanisms. However, when targeting nuclear or cytoplasmic antigens (e.g. amphiphysin-IgG or collapsin response mediator protein-5-IgG [CRMP5-IgG or anti-CV2) they are markers of a T-cell effector mediated injury as they are inaccessible to immune attack in situ, but peptides from intracellular proteins are displayed on upregulated MHC class 1 molecules in a pro-inflammatory cytokine milieu and then accessible to peptide specific cytotoxic T-cells.