Voltage-gated calcium channel-associated Lambert-Eaton myasthenic syndrome (Q96654): Difference between revisions
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A síndrome miastênica de Lambert-Eaton é uma doença autoimune humana rara da junção neuromuscular causada pela presença de anticorpos dirigidos contra canais de cálcio voltagem dependentes localizados na membrana pré-sináptica de seus terminais nervosos motores, levando assim à redução da transmissão neuromuscular. Em aproximadamente 50% dos pacientes, a síndrome miastênica de Lambert-Eaton é refletida por uma manifestação paraneoplásica e mais comumente associada a um carcinoma pulmonar de células pequenas cujas células também expressam canais de cálcio voltagem dependentes em sua membrana plasmática. | |||
| description / en | description / en | ||
Lambert-Eaton myasthenic syndrome is a rare human autoimmune disorder of the neuromuscular junction caused by the presence of antibodies directed against voltage-gated calcium channels localised in the presynaptic membrane of their motor nerve terminals, thus leading to reduced neuromuscular transmission. In approximately 50% of the patients, Lambert-Eaton myasthenic syndrome is reflected by a paraneoplastic manifestation and most commonly associated with a small cell lung carcinoma whose cells also express voltage-gated calcium channels in their plasma membrane. | |||
Revision as of 12:41, 16 August 2026
Lambert-Eaton myasthenic syndrome is a rare human autoimmune disorder of the neuromuscular junction caused by the presence of antibodies directed against voltage-gated calcium channels localised in the presynaptic membrane of their motor nerve terminals, thus leading to reduced neuromuscular transmission. In approximately 50% of the patients, Lambert-Eaton myasthenic syndrome is reflected by a paraneoplastic manifestation and most commonly associated with a small cell lung carcinoma whose cells also express voltage-gated calcium channels in their plasma membrane.
| Language | Label | Description | Also known as |
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| default for all languages | ID_97949388 |
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| English | Voltage-gated calcium channel-associated Lambert-Eaton myasthenic syndrome |
Lambert-Eaton myasthenic syndrome is a rare human autoimmune disorder of the neuromuscular junction caused by the presence of antibodies directed against voltage-gated calcium channels localised in the presynaptic membrane of their motor nerve terminals, thus leading to reduced neuromuscular transmission. In approximately 50% of the patients, Lambert-Eaton myasthenic syndrome is reflected by a paraneoplastic manifestation and most commonly associated with a small cell lung carcinoma whose cells also express voltage-gated calcium channels in their plasma membrane. |
