Acinar cell carcinoma of pancreas (Q94573): Difference between revisions
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| description / pt-br | description / pt-br | ||
O carcinoma de células acinares é uma neoplasia epitelial maligna composta por células com semelhança morfológica com as células acinares e com evidência de produção de enzimas exócrinas pancreáticas. A maioria dos carcinomas de células acinares apresenta sintomas inespecíficos. Eles geralmente se comprimem em vez de se infiltrar nas estruturas adjacentes. A síndrome de hipersecreção de lipase com sintomas clínicos incluindo necrose de gordura subcutânea e poliartralgia ocorre em 10-15% dos pacientes. Grosseiramente, a maioria dos carcinomas de células acinares são grandes, bem demarcados, macios e carnudos. Microscopicamente, são celulares com pouco estroma desmoplásico. A marcação imuno-histoquímica revelará a expressão de enzimas exócrinas. Eles são muito agressivos e metástases são encontradas em metade dos pacientes na apresentação. | |||
| description / en | description / en | ||
Acinar cell carcinoma is a malignant epithelial neoplasm composed of cells with morphologically resemblance to acinar cells and with evidence of pancreatic exocrine enzyme production. Most acinar cell carcinomas present with nonspecific symptoms. They generally compress rather than infiltrate into adjacent structures. The lipase hypersecretion syndrome with clinical symptoms including subcutaneous fat necrosis and polyarthralgia occurs in 10-15% of patients. Grossly, most acinar cell carcinomas are large, well-demarcated, and soft and fleshy. Microscopically, they are cellular with little desmoplastic stroma. Immunohistochemical labeling will reveal the expression of exocrine enzymes. They are very aggressive and metastases are found in half of patients at presentation. | |||
Revision as of 09:49, 16 August 2026
Acinar cell carcinoma is a malignant epithelial neoplasm composed of cells with morphologically resemblance to acinar cells and with evidence of pancreatic exocrine enzyme production. Most acinar cell carcinomas present with nonspecific symptoms. They generally compress rather than infiltrate into adjacent structures. The lipase hypersecretion syndrome with clinical symptoms including subcutaneous fat necrosis and polyarthralgia occurs in 10-15% of patients. Grossly, most acinar cell carcinomas are large, well-demarcated, and soft and fleshy. Microscopically, they are cellular with little desmoplastic stroma. Immunohistochemical labeling will reveal the expression of exocrine enzymes. They are very aggressive and metastases are found in half of patients at presentation.
| Language | Label | Description | Also known as |
|---|---|---|---|
| default for all languages | ID_449785448 |
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| English | Acinar cell carcinoma of pancreas |
Acinar cell carcinoma is a malignant epithelial neoplasm composed of cells with morphologically resemblance to acinar cells and with evidence of pancreatic exocrine enzyme production. Most acinar cell carcinomas present with nonspecific symptoms. They generally compress rather than infiltrate into adjacent structures. The lipase hypersecretion syndrome with clinical symptoms including subcutaneous fat necrosis and polyarthralgia occurs in 10-15% of patients. Grossly, most acinar cell carcinomas are large, well-demarcated, and soft and fleshy. Microscopically, they are cellular with little desmoplastic stroma. Immunohistochemical labeling will reveal the expression of exocrine enzymes. They are very aggressive and metastases are found in half of patients at presentation. |
