Myasthenia gravis, seronegative (Q88656): Difference between revisions

In approximately 50% of the Acetylcholine receptor-seronegative patients with generalised Myasthenia Gravis (MG), no autoantibodies against Muscle-specific kinase (MuSK) or against AChRs could be detected by routine methods. In this group autoantibodies against the low-density lipoprotein receptor-related protein 4 (LRP4) have been identified in several dSN-MG sera with a frequency variation (7-32%). There are also double positive patients (with LRP4 and AChR or MuSK). Anti-agrin antibodies were detected in combination with autoantibodies against MuSK, LRP4, or AChRs in 10-15% of the generalised MG patients.