Myasthenia gravis, seronegative (Q88656): Difference between revisions
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Em aproximadamente 50% dos pacientes soronegativos para o receptor da acetilcolina com Miastenia Gravis generalizada (MG), nenhum autoanticorpo contra a quinase muscular específica (MuSK) ou contra AChRs pôde ser detectado por métodos de rotina. Neste grupo, autoanticorpos contra a proteína 4 relacionada ao receptor de lipoproteína de baixa densidade (LRP4) foram identificados no soro de vários destes pacientes com uma variação de frequência (7-32%). Existem também pacientes duplamente positivos (com LRP4 e AChR ou MuSK). Anticorpos anti-agrina foram detectados em combinação com autoanticorpos contra MuSK, LRP4 ou AChRs em 10-15% dos pacientes com MG generalizada. | |||
| description / en | description / en | ||
In approximately 50% of the Acetylcholine receptor-seronegative patients with generalised Myasthenia Gravis (MG), no autoantibodies against Muscle-specific kinase (MuSK) or against AChRs could be detected by routine methods. In this group autoantibodies against the low-density lipoprotein receptor-related protein 4 (LRP4) have been identified in several dSN-MG sera with a frequency variation (7-32%). There are also double positive patients (with LRP4 and AChR or MuSK). Anti-agrin antibodies were detected in combination with autoantibodies against MuSK, LRP4, or AChRs in 10-15% of the generalised MG patients. | |||
Revision as of 14:59, 15 August 2026
In approximately 50% of the Acetylcholine receptor-seronegative patients with generalised Myasthenia Gravis (MG), no autoantibodies against Muscle-specific kinase (MuSK) or against AChRs could be detected by routine methods. In this group autoantibodies against the low-density lipoprotein receptor-related protein 4 (LRP4) have been identified in several dSN-MG sera with a frequency variation (7-32%). There are also double positive patients (with LRP4 and AChR or MuSK). Anti-agrin antibodies were detected in combination with autoantibodies against MuSK, LRP4, or AChRs in 10-15% of the generalised MG patients.
| Language | Label | Description | Also known as |
|---|---|---|---|
| default for all languages | ID_1979177138 |
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| English | Myasthenia gravis, seronegative |
In approximately 50% of the Acetylcholine receptor-seronegative patients with generalised Myasthenia Gravis (MG), no autoantibodies against Muscle-specific kinase (MuSK) or against AChRs could be detected by routine methods. In this group autoantibodies against the low-density lipoprotein receptor-related protein 4 (LRP4) have been identified in several dSN-MG sera with a frequency variation (7-32%). There are also double positive patients (with LRP4 and AChR or MuSK). Anti-agrin antibodies were detected in combination with autoantibodies against MuSK, LRP4, or AChRs in 10-15% of the generalised MG patients. |
